1g2r: Difference between revisions

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 <StructureSection load='1g2r' size='340' side='right'caption='[[1g2r]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1g2r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"diplococcus_pneumoniae"_(klein_1884)_weichselbaum_1886 "diplococcus pneumoniae" (klein 1884) weichselbaum 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G2R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1G2R FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1g2r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G2R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1G2R FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.35&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1g2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g2r OCA], [http://pdbe.org/1g2r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1g2r RCSB], [http://www.ebi.ac.uk/pdbsum/1g2r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1g2r ProSAT], [http://www.topsan.org/Proteins/MCSG/1g2r TOPSAN]</span></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1g2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g2r OCA], [https://pdbe.org/1g2r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1g2r RCSB], [https://www.ebi.ac.uk/pdbsum/1g2r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1g2r ProSAT], [https://www.topsan.org/Proteins/MCSG/1g2r TOPSAN]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/A0A0H2UNW2_STRPN A0A0H2UNW2_STRPN]
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 17: / Line 20: @@
 </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1g2r ConSurf].
 <div style="clear:both"></div>
-<div style="background-color:#fffaf0;">
-== Publication Abstract from PubMed ==
-The structure of the YlxR protein of unknown function from Streptococcus pneumonia was determined to 1.35 A. YlxR is expressed from the nusA/infB operon in bacteria and belongs to a small protein family (COG2740) that shares a conserved sequence motif GRGA(Y/W). The family shows no significant amino-acid sequence similarity with other proteins. Three-wavelength diffraction MAD data were collected to 1.7 A from orthorhombic crystals using synchrotron radiation and the structure was determined using a semi-automated approach. The YlxR structure resembles a two-layer alpha/beta sandwich with the overall shape of a cylinder and shows no structural homology to proteins of known structure. Structural analysis revealed that the YlxR structure represents a new protein fold that belongs to the alpha-beta plait superfamily. The distribution of the electrostatic surface potential shows a large positively charged patch on one side of the protein, a feature often found in nucleic acid-binding proteins. Three sulfate ions bind to this positively charged surface. Analysis of potential binding sites uncovered several substantial clefts, with the largest spanning 3/4 of the protein. A similar distribution of binding sites and a large sharply bent cleft are observed in RNA-binding proteins that are unrelated in sequence and structure. It is proposed that YlxR is an RNA-binding protein.
-Streptococcus pneumonia YlxR at 1.35 A shows a putative new fold.,Osipiuk J, Gornicki P, Maj L, Dementieva I, Laskowski R, Joachimiak A Acta Crystallogr D Biol Crystallogr. 2001 Nov;57(Pt 11):1747-51. Epub 2001, Oct 25. PMID:11679764<ref>PMID:11679764</ref>
-From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-</div>
-<div class="pdbe-citations 1g2r" style="background-color:#fffaf0;"></div>
-== References ==
-<references/>
 __TOC__
 </StructureSection>
 [[Category: Large Structures]]
-[[Category: Gornicki, P]]
-[[Category: Joachimiak, A]]
-[[Category: Structural genomic]]
-[[Category: Maj, L]]
-[[Category: Osipiuk, J]]
-[[Category: Hypothetical]]
-[[Category: Mcsg]]
-[[Category: Nusa-infb operon]]
-[[Category: PSI, Protein structure initiative]]
 [[Category: Streptococcus pneumoniae]]
-[[Category: Unknown function]]
+[[Category: Gornicki P]]
+[[Category: Joachimiak A]]
+[[Category: Maj L]]
+[[Category: Osipiuk J]]