1fxa: Difference between revisions

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-[[Image:1fxa.gif|left|200px]]
- {{Structure
+==CRYSTALLIZATION AND STRUCTURE DETERMINATION TO 2.5-ANGSTROMS RESOLUTION OF THE OXIDIZED [2FE-2S] FERREDOXIN ISOLATED FROM ANABAENA 7120==
-|PDB= 1fxa |SIZE=350|CAPTION= <scene name='initialview01'>1fxa</scene>, resolution 2.5&Aring;
+<StructureSection load='1fxa' size='340' side='right'caption='[[1fxa]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND= <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>
+<table><tr><td colspan='2'>[[1fxa]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Nostoc_sp._PCC_7120_=_FACHB-418 Nostoc sp. PCC 7120 = FACHB-418]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FXA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FXA FirstGlance]. <br>
-|ACTIVITY=
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-|GENE=
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene></td></tr>
-|DOMAIN=
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fxa OCA], [https://pdbe.org/1fxa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fxa RCSB], [https://www.ebi.ac.uk/pdbsum/1fxa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fxa ProSAT]</span></td></tr>
-|RELATEDENTRY=
+</table>
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fxa OCA], [http://www.ebi.ac.uk/pdbsum/1fxa PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1fxa RCSB]</span>
+== Function ==
-}}
+[https://www.uniprot.org/uniprot/FER1_NOSS1 FER1_NOSS1] Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fx/1fxa_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fxa ConSurf].
+<div style="clear:both"></div>
-'''CRYSTALLIZATION AND STRUCTURE DETERMINATION TO 2.5-ANGSTROMS RESOLUTION OF THE OXIDIZED [2FE-2S] FERREDOXIN ISOLATED FROM ANABAENA 7120'''
+==See Also==
+*[[Ferredoxin 3D structures|Ferredoxin 3D structures]]
+__TOC__
-==Overview==
+</StructureSection>
-The molecular structure of the oxidized form of the [2Fe-2S] ferredoxin isolated from the cyanobacterium Anabaena species strain PCC 7120 has been determined by X-ray diffraction analysis to a nominal resolution of 2.5 A and refined to a crystallographic R factor of 18.7%. Crystals used in this investigation belong to the space group P2(1)2(1)2(1) with unit cell dimensions of a = 37.42 A, b = 38.12 A, and c = 147.12 A and two molecules in the asymmetric unit. The three-dimensional structure of this ferredoxin was solved by a method that combined X-ray data from one isomorphous heavy-atom derivative with noncrystallographic symmetry averaging and solvent flattening. As in other plant-type [2Fe-2S] ferredoxins, the iron-sulfur cluster is located toward the outer edge of the molecule, and the irons are tetrahedrally coordinated by both inorganic sulfurs and sulfurs provided by protein cysteine residues. The main secondary structural elements include four strands of beta-pleated sheet and three alpha-helical regions.
+[[Category: Large Structures]]
+[[Category: Nostoc sp. PCC 7120 = FACHB-418]]
-==About this Structure==
+[[Category: Benning MM]]
-FXA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Anabaena_sp. Anabaena sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FXA OCA].
+[[Category: Breiter DR]]
+[[Category: Holden HM]]
-==Reference==
+[[Category: Markley JL]]
-Crystallization and structure determination to 2.5-A resolution of the oxidized [2Fe-2S] ferredoxin isolated from Anabaena 7120., Rypniewski WR, Breiter DR, Benning MM, Wesenberg G, Oh BH, Markley JL, Rayment I, Holden HM, Biochemistry. 1991 Apr 30;30(17):4126-31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1902376 1902376]
+[[Category: Oh B-H]]
-[[Category: Anabaena sp.]]
+[[Category: Rayment I]]
-[[Category: Single protein]]
+[[Category: Rypniewski WR]]
-[[Category: Benning, M M.]]
+[[Category: Wesenberg G]]
-[[Category: Breiter, D R.]]
-[[Category: Holden, H M.]]
-[[Category: Markley, J L.]]
-[[Category: Oh, B H.]]
-[[Category: Rayment, I.]]
-[[Category: Rypniewski, W R.]]
-[[Category: Wesenberg, G.]]
-[[Category: electron transport]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:32:04 2008''