1ft0: Difference between revisions

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-{{Seed}}
-[[Image:1ft0.png|left|200px]]
-<!--
+==CRYSTAL STRUCTURE OF TRUNCATED HUMAN RHOGDI K113A MUTANT==
-The line below this paragraph, containing "STRUCTURE_1ft0", creates the "Structure Box" on the page.
+<StructureSection load='1ft0' size='340' side='right'caption='[[1ft0]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1ft0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FT0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FT0 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ft0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ft0 OCA], [https://pdbe.org/1ft0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ft0 RCSB], [https://www.ebi.ac.uk/pdbsum/1ft0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ft0 ProSAT]</span></td></tr>
-{{STRUCTURE_1ft0|  PDB=1ft0  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/GDIR1_HUMAN GDIR1_HUMAN] Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1 (By similarity).
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ft/1ft0_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ft0 ConSurf].
+<div style="clear:both"></div>
-===CRYSTAL STRUCTURE OF TRUNCATED HUMAN RHOGDI K113A MUTANT===
+==See Also==
+*[[Guanine nucleotide dissociation inhibitor|Guanine nucleotide dissociation inhibitor]]
+__TOC__
-<!--
+</StructureSection>
-The line below this paragraph, {{ABSTRACT_PUBMED_11320308}}, adds the Publication Abstract to the page
-(as it appears on PubMed at http://www.pubmed.gov), where 11320308 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_11320308}}
-==About this Structure==
-FT0 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FT0 OCA]. Relevant biological numbers for this protein at [http://bionumbers.hms.harvard.edu/search.aspx?log=y&task=searchbytrmorg&trm=%22immunoglobulin%22&org=%25 B10NUMB3R5]
-==Reference==
-<ref group="xtra">PMID:11320308</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Derewenda, Z S.]]
+[[Category: Large Structures]]
-[[Category: Garrard, S M.]]
+[[Category: Derewenda ZS]]
-[[Category: Longenecker, K L.]]
+[[Category: Garrard SM]]
-[[Category: Sheffield, P J.]]
+[[Category: Longenecker KL]]
-[[Category: Beta sandwich motif]]
+[[Category: Sheffield PJ]]
-[[Category: Gdp-dissociation inhibitor of rho gtpase]]
-[[Category: Immunoglobulin fold]]
-[[Category: Isoprenyl-binding domain]]
-[[Category: Signaling protein inhibitor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon May 25 07:58:05 2009''