1fn9: Difference between revisions

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-[[Image:1fn9.png|left|200px]]
-{{STRUCTURE_1fn9|  PDB=1fn9  |  SCENE=  }}
+==CRYSTAL STRUCTURE OF THE REOVIRUS OUTER CAPSID PROTEIN SIGMA 3==
+<StructureSection load='1fn9' size='340' side='right'caption='[[1fn9]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-===CRYSTAL STRUCTURE OF THE REOVIRUS OUTER CAPSID PROTEIN SIGMA 3===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1fn9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Reovirus_sp. Reovirus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FN9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FN9 FirstGlance]. <br>
-{{ABSTRACT_PUBMED_11230122}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fn9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fn9 OCA], [https://pdbe.org/1fn9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fn9 RCSB], [https://www.ebi.ac.uk/pdbsum/1fn9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fn9 ProSAT]</span></td></tr>
-[[1fn9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Reovirus_sp. Reovirus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FN9 OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/SIGM3_REOVD SIGM3_REOVD] Stimulates translation by blocking the activation of the dsRNA-dependent protein kinase EIF2AK2/PKR, thereby inhibiting the host interferon response. Sigma3 prevents the activation of EIF2AK2 by competing with the kinase for dsRNA-binding.<ref>PMID:9268168</ref>   The viral outer shell polypeptides, of which sigma-3 is one, impose structural constraints that prevent elongation of nascent transcripts by the RNA-dependent RNA polymerase lambda-3.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fn/1fn9_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fn9 ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Virus coat protein|Virus coat protein]]
+*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:011230122</ref><references group="xtra"/>
+__TOC__
-[[Category: Reovirus sp.]]
+</StructureSection>
-[[Category: Harrison, S C.]]
+[[Category: Large Structures]]
-[[Category: Jane-Valbuena, J.]]
+[[Category: Reovirus sp]]
-[[Category: Nibert, M L.]]
+[[Category: Harrison SC]]
-[[Category: Olland, A M.]]
+[[Category: Jane-Valbuena J]]
-[[Category: Schiff, L A.]]
+[[Category: Nibert ML]]
-[[Category: Viral protein]]
+[[Category: Olland AM]]
-[[Category: Zinc binding motif]]
+[[Category: Schiff LA]]