1fl9: Difference between revisions

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[[Image:1fl9.png|left|200px]]


{{STRUCTURE_1fl9|  PDB=1fl9  |  SCENE= }}
==THE YJEE PROTEIN==
 
<StructureSection load='1fl9' size='340' side='right'caption='[[1fl9]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
===THE YJEE PROTEIN===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1fl9]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FL9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FL9 FirstGlance]. <br>
{{ABSTRACT_PUBMED_12112691}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fl9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fl9 OCA], [https://pdbe.org/1fl9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fl9 RCSB], [https://www.ebi.ac.uk/pdbsum/1fl9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fl9 ProSAT]</span></td></tr>
[[1fl9]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FL9 OCA].  
</table>
 
== Function ==
==Reference==
[https://www.uniprot.org/uniprot/TSAE_HAEIN TSAE_HAEIN] Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD (By similarity). Displays ATPase activity in vitro.<ref>PMID:12112691</ref>  
<ref group="xtra">PMID:012112691</ref><references group="xtra"/>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fl/1fl9_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fl9 ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Haemophilus influenzae]]
[[Category: Haemophilus influenzae]]
[[Category: Gilliland, G L.]]
[[Category: Large Structures]]
[[Category: S2F, Structure 2.Function Project.]]
[[Category: Gilliland GL]]
[[Category: Teplyakov, A.]]
[[Category: Teplyakov A]]
[[Category: Nucleotide-binding fold]]
[[Category: S2f]]
[[Category: Structural genomic]]
[[Category: Structure 2 function project]]
[[Category: Unknown function]]

Latest revision as of 10:15, 7 February 2024

THE YJEE PROTEINTHE YJEE PROTEIN

Structural highlights

1fl9 is a 3 chain structure with sequence from Haemophilus influenzae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.5Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TSAE_HAEIN Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD (By similarity). Displays ATPase activity in vitro.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Teplyakov A, Obmolova G, Tordova M, Thanki N, Bonander N, Eisenstein E, Howard AJ, Gilliland GL. Crystal structure of the YjeE protein from Haemophilus influenzae: a putative Atpase involved in cell wall synthesis. Proteins. 2002 Aug 1;48(2):220-6. PMID:12112691 doi:10.1002/prot.10114

1fl9, resolution 2.50Å

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