1fkb: Difference between revisions

<table><tr><td colspan='2'>[[1fkb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FKB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FKB FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RAP:RAPAMYCIN+IMMUNOSUPPRESSANT+DRUG'>RAP</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fkb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fkb OCA], [https://pdbe.org/1fkb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fkb RCSB], [https://www.ebi.ac.uk/pdbsum/1fkb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fkb ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/FKB1A_HUMAN FKB1A_HUMAN] Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.<ref>PMID:9233797</ref> <ref>PMID:16720724</ref>  

*[[FKBP 3D structures|FKBP 3D structures]]

[[Category: Homo sapiens]]

[[Category: Clardy JC]]

[[Category: Schreiber SL]]

[[Category: Standaert RF]]

[[Category: Van Duyne GD]]