1fgs: Difference between revisions

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-{{Seed}}
-[[Image:1fgs.png|left|200px]]
-<!--
+==FOLYLPOLYGLUTAMATE SYNTHETASE FROM LACTOBACILLUS CASEI==
-The line below this paragraph, containing "STRUCTURE_1fgs", creates the "Structure Box" on the page.
+<StructureSection load='1fgs' size='340' side='right'caption='[[1fgs]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1fgs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lacticaseibacillus_casei Lacticaseibacillus casei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FGS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FGS FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene></td></tr>
-{{STRUCTURE_1fgs|  PDB=1fgs  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fgs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fgs OCA], [https://pdbe.org/1fgs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fgs RCSB], [https://www.ebi.ac.uk/pdbsum/1fgs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fgs ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/FPGS_LACCA FPGS_LACCA] Involved in the conversion of folates to polyglutamate derivatives, and likely functions in the retention of cellular folate pools. Catalyzes successive MgATP-dependent additions of glutamate to a pteroylmonoglutamate substrate, with a high preference for 5,10-methylenetetrahydrofolate (mTHF). Thus, metabolizes mTHF to the tetraglutamate derivative, but longer glutamate chain length products are not observed. Tetrahydrofolate (H4PteGlu) and 10-formyl-H4PteGlu are poorer folate substrates. In contrast to E.coli FolC, this enzyme does not display dihydrofolate synthase activity.<ref>PMID:18232714</ref> <ref>PMID:6138353</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fg/1fgs_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fgs ConSurf].
+<div style="clear:both"></div>
-===FOLYLPOLYGLUTAMATE SYNTHETASE FROM LACTOBACILLUS CASEI===
+==See Also==
+*[[Folylpolyglutamate synthase|Folylpolyglutamate synthase]]
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_9618466}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 9618466 is the PubMed ID number.
+</StructureSection>
--->
+[[Category: Lacticaseibacillus casei]]
-{{ABSTRACT_PUBMED_9618466}}
+[[Category: Large Structures]]
+[[Category: Baker E]]
-==About this Structure==
+[[Category: Bognar A]]
-FGS is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Lactobacillus_casei Lactobacillus casei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FGS OCA].
+[[Category: Smith C]]
+[[Category: Sun X]]
-==Reference==
-<ref group="xtra">PMID:9618466</ref><references group="xtra"/>
-[[Category: Lactobacillus casei]]
-[[Category: Tetrahydrofolate synthase]]
-[[Category: Baker, E.]]
-[[Category: Bognar, A.]]
-[[Category: Smith, C.]]
-[[Category: Sun, X.]]
-[[Category: Ligase]]
-[[Category: Synthetase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 00:32:42 2009''