1fa8: Difference between revisions

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[[Image:1fa8.png|left|200px]]


{{STRUCTURE_1fa8|  PDB=1fa8  |  SCENE=  }}
==CRYSTAL STRUCTURE OF THE APO FORM GLYOXALASE I OF ESCHERICHIA COLI==
 
<StructureSection load='1fa8' size='340' side='right'caption='[[1fa8]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
===CRYSTAL STRUCTURE OF THE APO FORM GLYOXALASE I OF ESCHERICHIA COLI===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1fa8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FA8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FA8 FirstGlance]. <br>
{{ABSTRACT_PUBMED_10913283}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fa8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fa8 OCA], [https://pdbe.org/1fa8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fa8 RCSB], [https://www.ebi.ac.uk/pdbsum/1fa8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fa8 ProSAT]</span></td></tr>
==About this Structure==
</table>
[[1fa8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FA8 OCA].  
== Function ==
[https://www.uniprot.org/uniprot/LGUL_ECOLI LGUL_ECOLI] Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.<ref>PMID:10913283</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fa/1fa8_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fa8 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Glyoxalase|Glyoxalase]]
*[[Glyoxalase 3D structures|Glyoxalase 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:010913283</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Lactoylglutathione lyase]]
[[Category: Large Structures]]
[[Category: Clugston, S L.]]
[[Category: Clugston SL]]
[[Category: He, M M.]]
[[Category: He MM]]
[[Category: Honek, J F.]]
[[Category: Honek JF]]
[[Category: Matthews, B W.]]
[[Category: Matthews BW]]
[[Category: Apo enzyme.]]
[[Category: Beta-alpha-beta-beta-beta motif]]
[[Category: Homodimer]]
[[Category: Lyase]]

Latest revision as of 10:12, 7 February 2024

CRYSTAL STRUCTURE OF THE APO FORM GLYOXALASE I OF ESCHERICHIA COLICRYSTAL STRUCTURE OF THE APO FORM GLYOXALASE I OF ESCHERICHIA COLI

Structural highlights

1fa8 is a 2 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.7Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

LGUL_ECOLI Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ He MM, Clugston SL, Honek JF, Matthews BW. Determination of the structure of Escherichia coli glyoxalase I suggests a structural basis for differential metal activation. Biochemistry. 2000 Aug 1;39(30):8719-27. PMID:10913283

1fa8, resolution 1.70Å

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