1f9f: Difference between revisions

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[[Image:1f9f.png|left|200px]]


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==CRYSTAL STRUCTURE OF THE HPV-18 E2 DNA-BINDING DOMAIN==
The line below this paragraph, containing "STRUCTURE_1f9f", creates the "Structure Box" on the page.
<StructureSection load='1f9f' size='340' side='right'caption='[[1f9f]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1f9f]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_papillomavirus_type_18 Human papillomavirus type 18]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F9F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F9F FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_1f9f| PDB=1f9f |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f9f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f9f OCA], [https://pdbe.org/1f9f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f9f RCSB], [https://www.ebi.ac.uk/pdbsum/1f9f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f9f ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/VE2_HPV18 VE2_HPV18] E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f9/1f9f_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1f9f ConSurf].
<div style="clear:both"></div>


===CRYSTAL STRUCTURE OF THE HPV-18 E2 DNA-BINDING DOMAIN===
==See Also==
 
*[[Regulatory protein E2|Regulatory protein E2]]
 
__TOC__
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</StructureSection>
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{{ABSTRACT_PUBMED_10906136}}
 
==About this Structure==
1F9F is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_papillomavirus_type_18 Human papillomavirus type 18]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F9F OCA].
 
==Reference==
The structural basis of DNA target discrimination by papillomavirus E2 proteins., Kim SS, Tam JK, Wang AF, Hegde RS, J Biol Chem. 2000 Oct 6;275(40):31245-54. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10906136 10906136]
[[Category: Human papillomavirus type 18]]
[[Category: Human papillomavirus type 18]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Hegde, R.]]
[[Category: Hegde R]]
[[Category: Kim, S S.]]
[[Category: Kim SS]]
[[Category: Tam, J.]]
[[Category: Tam J]]
[[Category: Wang, A F.]]
[[Category: Wang AF]]
[[Category: Activator]]
[[Category: Dimeric beta barrel]]
[[Category: Dna-binding]]
[[Category: Trans-acting factor]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 02:54:38 2008''

Latest revision as of 10:12, 7 February 2024

CRYSTAL STRUCTURE OF THE HPV-18 E2 DNA-BINDING DOMAINCRYSTAL STRUCTURE OF THE HPV-18 E2 DNA-BINDING DOMAIN

Structural highlights

1f9f is a 4 chain structure with sequence from Human papillomavirus type 18. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.9Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

VE2_HPV18 E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1f9f, resolution 1.90Å

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