1f9f: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older edit
m Protected "1f9f" [edit=sysop:move=sysop]
No edit summary
 
(8 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:1f9f.png|left|200px]]


{{STRUCTURE_1f9f| PDB=1f9f | SCENE= }}
==CRYSTAL STRUCTURE OF THE HPV-18 E2 DNA-BINDING DOMAIN==
<StructureSection load='1f9f' size='340' side='right'caption='[[1f9f]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1f9f]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_papillomavirus_type_18 Human papillomavirus type 18]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F9F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F9F FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f9f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f9f OCA], [https://pdbe.org/1f9f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f9f RCSB], [https://www.ebi.ac.uk/pdbsum/1f9f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f9f ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/VE2_HPV18 VE2_HPV18] E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f9/1f9f_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1f9f ConSurf].
<div style="clear:both"></div>


===CRYSTAL STRUCTURE OF THE HPV-18 E2 DNA-BINDING DOMAIN===
==See Also==
 
*[[Regulatory protein E2|Regulatory protein E2]]
 
__TOC__
==About this Structure==
</StructureSection>
[[1f9f]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_papillomavirus_type_18 Human papillomavirus type 18]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F9F OCA].
 
==Reference==
<ref group="xtra">PMID:010906136</ref><references group="xtra"/>
[[Category: Human papillomavirus type 18]]
[[Category: Human papillomavirus type 18]]
[[Category: Hegde, R.]]
[[Category: Large Structures]]
[[Category: Kim, S S.]]
[[Category: Hegde R]]
[[Category: Tam, J.]]
[[Category: Kim SS]]
[[Category: Wang, A F.]]
[[Category: Tam J]]
[[Category: Activator]]
[[Category: Wang AF]]
[[Category: Dimeric beta barrel]]
[[Category: Dna-binding]]
[[Category: Trans-acting factor]]
[[Category: Transcription]]

Latest revision as of 10:12, 7 February 2024

CRYSTAL STRUCTURE OF THE HPV-18 E2 DNA-BINDING DOMAINCRYSTAL STRUCTURE OF THE HPV-18 E2 DNA-BINDING DOMAIN

Structural highlights

1f9f is a 4 chain structure with sequence from Human papillomavirus type 18. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.9Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

VE2_HPV18 E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1f9f, resolution 1.90Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=1f9f&oldid=4043280"