1f8x: Difference between revisions

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{{STRUCTURE_1f8x|  PDB=1f8x  |  SCENE=  }}
==CRYSTAL STRUCTURE OF NUCLEOSIDE 2-DEOXYRIBOSYLTRANSFERASE==
 
<StructureSection load='1f8x' size='340' side='right'caption='[[1f8x]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
===CRYSTAL STRUCTURE OF NUCLEOSIDE 2-DEOXYRIBOSYLTRANSFERASE===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1f8x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lactobacillus_leichmannii Lactobacillus leichmannii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F8X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F8X FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f8x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f8x OCA], [https://pdbe.org/1f8x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f8x RCSB], [https://www.ebi.ac.uk/pdbsum/1f8x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f8x ProSAT]</span></td></tr>
[[1f8x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lactobacillus_leichmannii Lactobacillus leichmannii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F8X OCA].  
</table>
 
== Function ==
==Reference==
[https://www.uniprot.org/uniprot/NTD_LACLE NTD_LACLE] Catalyzes the cleavage of the glycosidic bond of 2'-deoxyribonucleosides and the transfer of the deoxyribosyl moiety to an acceptor purine or pyrimidine base.<ref>PMID:7797550</ref> <ref>PMID:8805514</ref>  
<ref group="xtra">PMID:008805514</ref><references group="xtra"/>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f8/1f8x_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1f8x ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Lactobacillus leichmannii]]
[[Category: Lactobacillus leichmannii]]
[[Category: Nucleoside deoxyribosyltransferase]]
[[Category: Large Structures]]
[[Category: Armstrong, S R.]]
[[Category: Armstrong SR]]
[[Category: Cook, W J.]]
[[Category: Cook WJ]]
[[Category: Ealick, S E.]]
[[Category: Ealick SE]]
[[Category: Short, S A.]]
[[Category: Short SA]]
[[Category: Active site]]
[[Category: Alpha/beta protein]]
[[Category: Biocatalyst]]
[[Category: Nucleoside]]
[[Category: Transferase]]

Latest revision as of 10:12, 7 February 2024

CRYSTAL STRUCTURE OF NUCLEOSIDE 2-DEOXYRIBOSYLTRANSFERASECRYSTAL STRUCTURE OF NUCLEOSIDE 2-DEOXYRIBOSYLTRANSFERASE

Structural highlights

1f8x is a 2 chain structure with sequence from Lactobacillus leichmannii. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.5Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

NTD_LACLE Catalyzes the cleavage of the glycosidic bond of 2'-deoxyribonucleosides and the transfer of the deoxyribosyl moiety to an acceptor purine or pyrimidine base.[1] [2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Porter DJ, Merrill BM, Short SA. Identification of the active site nucleophile in nucleoside 2-deoxyribosyltransferase as glutamic acid 98. J Biol Chem. 1995 Jun 30;270(26):15551-6. PMID:7797550
  2. ↑ Armstrong SR, Cook WJ, Short SA, Ealick SE. Crystal structures of nucleoside 2-deoxyribosyltransferase in native and ligand-bound forms reveal architecture of the active site. Structure. 1996 Jan 15;4(1):97-107. PMID:8805514

1f8x, resolution 2.50Å

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