1f2i: Difference between revisions

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[[Image:1f2i.png|left|200px]]


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==COCRYSTAL STRUCTURE OF SELECTED ZINC FINGER DIMER BOUND TO DNA==
The line below this paragraph, containing "STRUCTURE_1f2i", creates the "Structure Box" on the page.
<StructureSection load='1f2i' size='340' side='right'caption='[[1f2i]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1f2i]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F2I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F2I FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_1f2i|  PDB=1f2i  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f2i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f2i OCA], [https://pdbe.org/1f2i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f2i RCSB], [https://www.ebi.ac.uk/pdbsum/1f2i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f2i ProSAT]</span></td></tr>
 
</table>
===COCRYSTAL STRUCTURE OF SELECTED ZINC FINGER DIMER BOUND TO DNA===
== Function ==
 
[https://www.uniprot.org/uniprot/EGR1_MOUSE EGR1_MOUSE] Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation.
 
== Evolutionary Conservation ==
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f2/1f2i_consurf.spt"</scriptWhenChecked>
{{ABSTRACT_PUBMED_11427887}}
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    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
1F2I is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F2I OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1f2i ConSurf].
 
<div style="clear:both"></div>
==Reference==
__TOC__
Selected peptide extension contacts hydrophobic patch on neighboring zinc finger and mediates dimerization on DNA., Wang BS, Grant RA, Pabo CO, Nat Struct Biol. 2001 Jul;8(7):589-93. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11427887 11427887]
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Single protein]]
[[Category: Grant RA]]
[[Category: Grant, R A.]]
[[Category: Pabo CO]]
[[Category: Pabo, C O.]]
[[Category: Wang BS]]
[[Category: Wang, B S.]]
[[Category: Cooperativity]]
[[Category: Dimer]]
[[Category: Protein-dna complex]]
[[Category: Zinc finger]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 02:23:45 2008''

Latest revision as of 10:09, 7 February 2024

COCRYSTAL STRUCTURE OF SELECTED ZINC FINGER DIMER BOUND TO DNACOCRYSTAL STRUCTURE OF SELECTED ZINC FINGER DIMER BOUND TO DNA

Structural highlights

1f2i is a 12 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.35Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

EGR1_MOUSE Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

1f2i, resolution 2.35Å

Drag the structure with the mouse to rotate

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