1ew4: Difference between revisions

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<StructureSection load='1ew4' size='340' side='right'caption='[[1ew4]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
<StructureSection load='1ew4' size='340' side='right'caption='[[1ew4]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1ew4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EW4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EW4 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1ew4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EW4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EW4 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ew4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ew4 OCA], [https://pdbe.org/1ew4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ew4 RCSB], [https://www.ebi.ac.uk/pdbsum/1ew4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ew4 ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ew4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ew4 OCA], [https://pdbe.org/1ew4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ew4 RCSB], [https://www.ebi.ac.uk/pdbsum/1ew4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ew4 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CYAY_ECOLI CYAY_ECOLI]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ew4 ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ew4 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Friedreich ataxia is an autosomal recessive neurodegenerative disease caused by defects in the FRDA gene, which encodes a mitochondrial protein called frataxin. Frataxin is evolutionarily conserved, with homologs identified in mammals, worms, yeast, and bacteria. The CyaY proteins of gamma-purple bacteria are believed to be closely related to the ancestor of frataxin. In this study, we have determined the crystal structure of the CyaY protein from Escherichia coli at 1.4-A resolution. It reveals a protein fold consisting of a six-stranded antiparallel beta-sheet flanked on one side by two alpha-helices. This fold is likely to be shared by all members of the conserved frataxin family. This study also provides a framework for the interpretation of disease-associated mutations in frataxin and for understanding the possible functions of this protein family.
Crystal structure of Escherichia coli CyaY protein reveals a previously unidentified fold for the evolutionarily conserved frataxin family.,Cho SJ, Lee MG, Yang JK, Lee JY, Song HK, Suh SW Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):8932-7. PMID:10908679<ref>PMID:10908679</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1ew4" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Frataxin 3D Structures|Frataxin 3D Structures]]
*[[Frataxin 3D Structures|Frataxin 3D Structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus coli migula 1895]]
[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Cho, S]]
[[Category: Cho S]]
[[Category: Lee, J Y]]
[[Category: Lee JY]]
[[Category: Lee, M G]]
[[Category: Lee MG]]
[[Category: Song, H K]]
[[Category: Song HK]]
[[Category: Suh, S W]]
[[Category: Suh SW]]
[[Category: Yang, J K]]
[[Category: Yang JK]]
[[Category: Cyay]]
[[Category: Frataxin family]]
[[Category: Friedreich ataxia]]
[[Category: Iron homeostasis]]
[[Category: Unknown function]]

Latest revision as of 10:07, 7 February 2024

CRYSTAL STRUCTURE OF ESCHERICHIA COLI CYAY PROTEIN REVEALS A NOVEL FOLD FOR THE FRATAXIN FAMILYCRYSTAL STRUCTURE OF ESCHERICHIA COLI CYAY PROTEIN REVEALS A NOVEL FOLD FOR THE FRATAXIN FAMILY

Structural highlights

1ew4 is a 1 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.4Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CYAY_ECOLI

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1ew4, resolution 1.40Å

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OCA
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