1euj: Difference between revisions

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OCA

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-[[Image:1euj.gif|left|200px]]<br />
-<applet load="1euj" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="1euj, resolution 1.8&Aring;" />
-'''A NOVEL ANTI-TUMOR CYTOKINE CONTAINS A RNA-BINDING MOTIF PRESENT IN AMINOACYL-TRNA SYNTHETASES'''<br />
-==Overview==
+==A NOVEL ANTI-TUMOR CYTOKINE CONTAINS A RNA-BINDING MOTIF PRESENT IN AMINOACYL-TRNA SYNTHETASES==
-Endothelial monocyte-activating polypeptide II (EMAP II) is a novel, pro-apoptotic cytokine that shares sequence homology with the C-terminal, regions of several tRNA synthetases. Pro-EMAP II, the precursor of EMAP, II, is associated with the multi-tRNA synthetase complex and facilitates, aminoacylation activity. The structure of human EMAP II, solved at 1.8 A, resolution, revealed the oligomer-binding fold for binding different tRNAs, and a domain that is structurally homologous to other chemokines. The, similar structures to the RNA binding motif of EMAP II was previously, observed in the anticodon binding domain of yeast Asp-tRNA synthetase, (AspRSSC) and the B2 domain of Thermus thermophilus Phe-tRNA synthetase., The RNA binding pattern of EMAP II is likely to be nonspecific, in, contrast to the AspRSSC. The peptide sequence that is responsible for, cytokine activity is located, for the most part, in the beta1 strand. It, is divided into two regions by a neighboring loop.
+<StructureSection load='1euj' size='340' side='right'caption='[[1euj]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
+== Structural highlights ==
-==About this Structure==
+<table><tr><td colspan='2'>[[1euj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EUJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EUJ FirstGlance]. <br>
-EUJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1EUJ OCA].
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1euj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1euj OCA], [https://pdbe.org/1euj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1euj RCSB], [https://www.ebi.ac.uk/pdbsum/1euj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1euj ProSAT]</span></td></tr>
-==Reference==
+</table>
-A novel anti-tumor cytokine contains an RNA binding motif present in aminoacyl-tRNA synthetases., Kim Y, Shin J, Li R, Cheong C, Kim K, Kim S, J Biol Chem. 2000 Sep 1;275(35):27062-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10852899 10852899]
+== Disease ==
+[https://www.uniprot.org/uniprot/AIMP1_HUMAN AIMP1_HUMAN] Defects in AIMP1 are the cause of leukodystrophy hypomyelinating type 3 (HLD3) [MIM:[https://omim.org/entry/260600 260600]. A severe autosomal recessive hypomyelinating leukodystrophy characterized by early infantile onset of global developmental delay, lack of development, lack of speech acquisition, and peripheral spasticity associated with decreased myelination in the central nervous system.<ref>PMID:21092922</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/AIMP1_HUMAN AIMP1_HUMAN] Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblast proliferation and wound repair. Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum. Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7.<ref>PMID:10358004</ref> <ref>PMID:11306575</ref> <ref>PMID:12237313</ref> <ref>PMID:11818442</ref> <ref>PMID:19362550</ref> <ref>PMID:11157763</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eu/1euj_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1euj ConSurf].
+<div style="clear:both"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Cheong, C.]]
+[[Category: Cheong C]]
-[[Category: Kim, S.]]
+[[Category: Kim S]]
-[[Category: Kim, Y.]]
+[[Category: Kim Y]]
-[[Category: Li, R.]]
+[[Category: Li R]]
-[[Category: Shin, J.]]
+[[Category: Shin J]]
-[[Category: apoptosis]]
-[[Category: cytokine]]
-[[Category: emap 2]]
-[[Category: emap ii]]
-[[Category: rna binding motif]]
-[[Category: trna synthetase]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 16:46:47 2007''