1etx: Difference between revisions

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[[Image:1etx.png|left|200px]]


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==THE CRYSTAL STRUCTURE OF E. COLI FIS MUTANT Q74A==
The line below this paragraph, containing "STRUCTURE_1etx", creates the "Structure Box" on the page.
<StructureSection load='1etx' size='340' side='right'caption='[[1etx]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1etx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ETX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ETX FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1etx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1etx OCA], [https://pdbe.org/1etx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1etx RCSB], [https://www.ebi.ac.uk/pdbsum/1etx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1etx ProSAT]</span></td></tr>
{{STRUCTURE_1etx| PDB=1etx |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/FIS_ECOLI FIS_ECOLI] Activates ribosomal RNA transcription, as well other genes. Plays a direct role in upstream activation of rRNA promoters. Binds to a recombinational enhancer sequence that is required to stimulate hin-mediated DNA inversion. Prevents initiation of DNA replication from oriC.<ref>PMID:2209559</ref> <ref>PMID:8836178</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/et/1etx_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1etx ConSurf].
<div style="clear:both"></div>


===THE CRYSTAL STRUCTURE OF E. COLI FIS MUTANT Q74A===
==See Also==
 
*[[FIS protein|FIS protein]]
 
== References ==
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{{ABSTRACT_PUBMED_11183780}}
 
==About this Structure==
1ETX is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ETX OCA].
 
==Reference==
<ref group="xtra">PMID:11183780</ref><references group="xtra"/>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Cheng, Y S.]]
[[Category: Large Structures]]
[[Category: Johnson, R C.]]
[[Category: Cheng YS]]
[[Category: Yang, W Z.]]
[[Category: Johnson RC]]
[[Category: Yuan, H S.]]
[[Category: Yang WZ]]
[[Category: Dna-binding protein]]
[[Category: Yuan HS]]
[[Category: Transcriptional activation region]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 22:28:08 2009''

Latest revision as of 10:06, 7 February 2024

THE CRYSTAL STRUCTURE OF E. COLI FIS MUTANT Q74ATHE CRYSTAL STRUCTURE OF E. COLI FIS MUTANT Q74A

Structural highlights

1etx is a 2 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.9Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

FIS_ECOLI Activates ribosomal RNA transcription, as well other genes. Plays a direct role in upstream activation of rRNA promoters. Binds to a recombinational enhancer sequence that is required to stimulate hin-mediated DNA inversion. Prevents initiation of DNA replication from oriC.[1] [2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Ross W, Thompson JF, Newlands JT, Gourse RL. E.coli Fis protein activates ribosomal RNA transcription in vitro and in vivo. EMBO J. 1990 Nov;9(11):3733-42. PMID:2209559
  2. ↑ Wold S, Crooke E, Skarstad K. The Escherichia coli Fis protein prevents initiation of DNA replication from oriC in vitro. Nucleic Acids Res. 1996 Sep 15;24(18):3527-32. PMID:8836178

1etx, resolution 1.90Å

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