1em9: Difference between revisions

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[[Image:1em9.png|left|200px]]


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==ROUS SARCOMA VIRUS CAPSID PROTEIN: N-TERMINAL DOMAIN==
The line below this paragraph, containing "STRUCTURE_1em9", creates the "Structure Box" on the page.
<StructureSection load='1em9' size='340' side='right'caption='[[1em9]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1em9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rous_sarcoma_virus_-_Prague_C Rous sarcoma virus - Prague C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EM9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EM9 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
{{STRUCTURE_1em9| PDB=1em9 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1em9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1em9 OCA], [https://pdbe.org/1em9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1em9 RCSB], [https://www.ebi.ac.uk/pdbsum/1em9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1em9 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GAG_RSVP GAG_RSVP] Capsid protein p27 forms the spherical core of the virus that encapsulates the genomic RNA-nucleocapsid complex (By similarity).  The aspartyl protease mediates proteolytic cleavages of Gag and Gag-Pol polyproteins during or shortly after the release of the virion from the plasma membrane. Cleavages take place as an ordered, step-wise cascade to yield mature proteins. This process is called maturation. Displays maximal activity during the budding process just prior to particle release from the cell (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/em/1em9_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1em9 ConSurf].
<div style="clear:both"></div>


===ROUS SARCOMA VIRUS CAPSID PROTEIN: N-TERMINAL DOMAIN===
==See Also==
 
*[[Gag polyprotein 3D structures|Gag polyprotein 3D structures]]
 
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
<!--
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The line below this paragraph, {{ABSTRACT_PUBMED_10873863}}, adds the Publication Abstract to the page
</StructureSection>
(as it appears on PubMed at http://www.pubmed.gov), where 10873863 is the PubMed ID number.
[[Category: Large Structures]]
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[[Category: Rous sarcoma virus - Prague C]]
{{ABSTRACT_PUBMED_10873863}}
[[Category: Eisenmesser EZ]]
 
[[Category: Fitzon-Ostendorp T]]
==About this Structure==
[[Category: Kingston RL]]
1EM9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rous_sarcoma_virus Rous sarcoma virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EM9 OCA].
[[Category: Post CB]]
 
[[Category: Rossmann MG]]
==Reference==
[[Category: Schatz GW]]
Structure and self-association of the Rous sarcoma virus capsid protein., Kingston RL, Fitzon-Ostendorp T, Eisenmesser EZ, Schatz GW, Vogt VM, Post CB, Rossmann MG, Structure. 2000 Jun 15;8(6):617-28. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10873863 10873863]
[[Category: Vogt VM]]
[[Category: Rous sarcoma virus]]
[[Category: Single protein]]
[[Category: Eisenmesser, E Z.]]
[[Category: Fitzon-Ostendorp, T.]]
[[Category: Kingston, R L.]]
[[Category: Post, C B.]]
[[Category: Rossmann, M G.]]
[[Category: Schatz, G W.]]
[[Category: Vogt, V M.]]
[[Category: Virus/viral protein]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 00:58:30 2008''

Latest revision as of 10:04, 7 February 2024

ROUS SARCOMA VIRUS CAPSID PROTEIN: N-TERMINAL DOMAINROUS SARCOMA VIRUS CAPSID PROTEIN: N-TERMINAL DOMAIN

Structural highlights

1em9 is a 2 chain structure with sequence from Rous sarcoma virus - Prague C. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.05Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GAG_RSVP Capsid protein p27 forms the spherical core of the virus that encapsulates the genomic RNA-nucleocapsid complex (By similarity). The aspartyl protease mediates proteolytic cleavages of Gag and Gag-Pol polyproteins during or shortly after the release of the virion from the plasma membrane. Cleavages take place as an ordered, step-wise cascade to yield mature proteins. This process is called maturation. Displays maximal activity during the budding process just prior to particle release from the cell (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1em9, resolution 2.05Å

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