1em8: Difference between revisions

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[[Image:1em8.png|left|200px]]


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==Crystal structure of chi and psi subunit heterodimer from DNA POL III==
The line below this paragraph, containing "STRUCTURE_1em8", creates the "Structure Box" on the page.
<StructureSection load='1em8' size='340' side='right'caption='[[1em8]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1em8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EM8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EM8 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1em8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1em8 OCA], [https://pdbe.org/1em8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1em8 RCSB], [https://www.ebi.ac.uk/pdbsum/1em8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1em8 ProSAT]</span></td></tr>
{{STRUCTURE_1em8| PDB=1em8 |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/HOLC_ECOLI HOLC_ECOLI] DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/em/1em8_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1em8 ConSurf].
<div style="clear:both"></div>


===Crystal structure of chi and psi subunit heterodimer from DNA POL III===
==See Also==
 
*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
 
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</StructureSection>
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{{ABSTRACT_PUBMED_14717711}}
 
==About this Structure==
1EM8 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EM8 OCA].
 
==Reference==
Crystal structure of the chi:psi sub-assembly of the Escherichia coli DNA polymerase clamp-loader complex., Gulbis JM, Kazmirski SL, Finkelstein J, Kelman Z, O'Donnell M, Kuriyan J, Eur J Biochem. 2004 Jan;271(2):439-49. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14717711 14717711]
[[Category: DNA-directed DNA polymerase]]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Protein complex]]
[[Category: Large Structures]]
[[Category: Donnell, M O.]]
[[Category: Finkelstein J]]
[[Category: Finkelstein, J.]]
[[Category: Gulbis JM]]
[[Category: Gulbis, J M.]]
[[Category: Kuriyan J]]
[[Category: Kuriyan, J.]]
[[Category: O'Donnell M]]
[[Category: Alpha-beta fold]]
[[Category: Clamp-loader]]
[[Category: Dna pol iii]]
[[Category: Heterodimer]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 00:58:25 2008''

Latest revision as of 10:04, 7 February 2024

Crystal structure of chi and psi subunit heterodimer from DNA POL IIICrystal structure of chi and psi subunit heterodimer from DNA POL III

Structural highlights

1em8 is a 4 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.1Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

HOLC_ECOLI DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1em8, resolution 2.10Å

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
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