1efd: Difference between revisions

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[[Image:1efd.png|left|200px]]


{{STRUCTURE_1efd|  PDB=1efd  |  SCENE=  }}
==PERIPLASMIC FERRIC SIDEROPHORE BINDING PROTEIN FHUD COMPLEXED WITH GALLICHROME==
 
<StructureSection load='1efd' size='340' side='right'caption='[[1efd]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
===PERIPLASMIC FERRIC SIDEROPHORE BINDING PROTEIN FHUD COMPLEXED WITH GALLICHROME===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1efd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EFD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EFD FirstGlance]. <br>
{{ABSTRACT_PUBMED_10742172}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GCR:GALLICHROME'>GCR</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1efd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1efd OCA], [https://pdbe.org/1efd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1efd RCSB], [https://www.ebi.ac.uk/pdbsum/1efd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1efd ProSAT]</span></td></tr>
[[1efd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EFD OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/FHUD_ECOLI FHUD_ECOLI] Part of the ABC transporter complex FhuCDB involved in iron(3+)-hydroxamate import. Binds the iron(3+)-hydroxamate complex and transfers it to the membrane-bound permease. Required for the transport of all iron(3+)-hydroxamate siderophores such as ferrichrome, gallichrome, desferrioxamine, coprogen, aerobactin, shizokinen, rhodotorulic acid and the antibiotic albomycin.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ef/1efd_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1efd ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[FhuD|FhuD]]
*[[Ferric hydroxamate uptake receptor|Ferric hydroxamate uptake receptor]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:010742172</ref><references group="xtra"/>
[[Category: Escherichia coli]]
[[Category: Clarke, T E.]]
[[Category: Dougan, D R.]]
[[Category: Ku, S Y.]]
[[Category: Tari, L W.]]
[[Category: Vogel, H J.]]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Ferric siderophore binding protein]]
[[Category: Large Structures]]
[[Category: Fhud complex with gallichrome]]
[[Category: Clarke TE]]
[[Category: Metal transport]]
[[Category: Dougan DR]]
[[Category: Periplasmic binding protein-siderophore complex]]
[[Category: Ku S-Y]]
[[Category: Tari LW]]
[[Category: Vogel HJ]]

Latest revision as of 10:01, 7 February 2024

PERIPLASMIC FERRIC SIDEROPHORE BINDING PROTEIN FHUD COMPLEXED WITH GALLICHROMEPERIPLASMIC FERRIC SIDEROPHORE BINDING PROTEIN FHUD COMPLEXED WITH GALLICHROME

Structural highlights

1efd is a 1 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.9Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

FHUD_ECOLI Part of the ABC transporter complex FhuCDB involved in iron(3+)-hydroxamate import. Binds the iron(3+)-hydroxamate complex and transfers it to the membrane-bound permease. Required for the transport of all iron(3+)-hydroxamate siderophores such as ferrichrome, gallichrome, desferrioxamine, coprogen, aerobactin, shizokinen, rhodotorulic acid and the antibiotic albomycin.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1efd, resolution 1.90Å

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