1dq8: Difference between revisions

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-{{Seed}}
-[[Image:1dq8.png|left|200px]]
-<!--
+==COMPLEX OF THE CATALYTIC PORTION OF HUMAN HMG-COA REDUCTASE WITH HMG AND COA==
-The line below this paragraph, containing "STRUCTURE_1dq8", creates the "Structure Box" on the page.
+<StructureSection load='1dq8' size='340' side='right'caption='[[1dq8]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1dq8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DQ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DQ8 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=MAH:3-HYDROXY-3-METHYL-GLUTARIC+ACID'>MAH</scene></td></tr>
-{{STRUCTURE_1dq8|  PDB=1dq8  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dq8 OCA], [https://pdbe.org/1dq8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dq8 RCSB], [https://www.ebi.ac.uk/pdbsum/1dq8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dq8 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/HMDH_HUMAN HMDH_HUMAN] Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dq/1dq8_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dq8 ConSurf].
+<div style="clear:both"></div>
-===COMPLEX OF THE CATALYTIC PORTION OF HUMAN HMG-COA REDUCTASE WITH HMG AND COA===
+==See Also==
+*[[HMG-CoA Reductase|HMG-CoA Reductase]]
+*[[HMG-CoA Reductase 3D structures|HMG-CoA Reductase 3D structures]]
-<!--
+__TOC__
-The line below this paragraph, {{ABSTRACT_PUBMED_10698924}}, adds the Publication Abstract to the page
+</StructureSection>
-(as it appears on PubMed at http://www.pubmed.gov), where 10698924 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_10698924}}
-==About this Structure==
-DQ8 is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DQ8 OCA].
-==Reference==
-<ref group="xtra">PMID:10698924</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Buchanan, S K.]]
+[[Category: Large Structures]]
-[[Category: Deisenhofer, J.]]
+[[Category: Buchanan SK]]
-[[Category: Istvan, E S.]]
+[[Category: Deisenhofer J]]
-[[Category: Palnitkar, M.]]
+[[Category: Istvan ES]]
-[[Category: Cholesterol biosynthesis]]
+[[Category: Palnitkar M]]
-[[Category: Hmg-coa]]
-[[Category: Nadph]]
-[[Category: Oxidoreductase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 04:11:02 2009''