1dos: Difference between revisions

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[[Image:1dos.png|left|200px]]


{{STRUCTURE_1dos|  PDB=1dos  |  SCENE=  }}
==STRUCTURE OF FRUCTOSE-BISPHOSPHATE ALDOLASE==
 
<StructureSection load='1dos' size='340' side='right'caption='[[1dos]], [[Resolution|resolution]] 1.67&Aring;' scene=''>
===STRUCTURE OF FRUCTOSE-BISPHOSPHATE ALDOLASE===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1dos]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DOS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DOS FirstGlance]. <br>
{{ABSTRACT_PUBMED_8836102}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.67&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dos OCA], [https://pdbe.org/1dos PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dos RCSB], [https://www.ebi.ac.uk/pdbsum/1dos PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dos ProSAT]</span></td></tr>
[[1dos]] is a 2 chain structure of [[Aldolase]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DOS OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/ALF_ECOLI ALF_ECOLI] Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.<ref>PMID:10712619</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/do/1dos_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dos ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Aldolase|Aldolase]]
*[[Aldolase 3D structures|Aldolase 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:008836102</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Fructose-bisphosphate aldolase]]
[[Category: Large Structures]]
[[Category: Blom, N.]]
[[Category: Blom N]]
[[Category: Coulombe, R.]]
[[Category: Coulombe R]]
[[Category: Sygusch, J.]]
[[Category: Sygusch J]]
[[Category: Tetreault, S.]]
[[Category: Tetreault S]]
[[Category: 6-bisphosphate aldolase]]
[[Category: Classii fructose 1]]
[[Category: Glycolysis]]
[[Category: Lyase]]

Latest revision as of 09:57, 7 February 2024

STRUCTURE OF FRUCTOSE-BISPHOSPHATE ALDOLASESTRUCTURE OF FRUCTOSE-BISPHOSPHATE ALDOLASE

Structural highlights

1dos is a 2 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.67Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ALF_ECOLI Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Zgiby SM, Thomson GJ, Qamar S, Berry A. Exploring substrate binding and discrimination in fructose1, 6-bisphosphate and tagatose 1,6-bisphosphate aldolases. Eur J Biochem. 2000 Mar;267(6):1858-68. PMID:10712619

1dos, resolution 1.67Å

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