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[[Image:1diw.png|left|200px]]


{{STRUCTURE_1diw|  PDB=1diw  |  SCENE=  }}
==THE HC FRAGMENT OF TETANUS TOXIN COMPLEXED WITH GALACTOSE==
 
<StructureSection load='1diw' size='340' side='right'caption='[[1diw]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
===THE HC FRAGMENT OF TETANUS TOXIN COMPLEXED WITH GALACTOSE===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1diw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DIW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DIW FirstGlance]. <br>
{{ABSTRACT_PUBMED_10722735}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1diw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1diw OCA], [https://pdbe.org/1diw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1diw RCSB], [https://www.ebi.ac.uk/pdbsum/1diw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1diw ProSAT]</span></td></tr>
[[1diw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DIW OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/TETX_CLOTE TETX_CLOTE] Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-|-Phe-77' bond of synaptobrevin-2.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/di/1diw_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1diw ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Tetanus toxin|Tetanus toxin]]
*[[Tetanus toxin|Tetanus toxin]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:010722735</ref><references group="xtra"/>
[[Category: Clostridium tetani]]
[[Category: Clostridium tetani]]
[[Category: Tentoxilysin]]
[[Category: Large Structures]]
[[Category: Black, I.]]
[[Category: Black I]]
[[Category: Charles, I G.]]
[[Category: Charles IG]]
[[Category: Emsley, P.]]
[[Category: Emsley P]]
[[Category: Fairweather, N F.]]
[[Category: Fairweather NF]]
[[Category: Fotinou, C.]]
[[Category: Fotinou C]]
[[Category: Hewitt, E.]]
[[Category: Hewitt E]]
[[Category: Isaacs, N W.]]
[[Category: Isaacs NW]]
[[Category: Watts, C.]]
[[Category: Watts C]]
[[Category: Beta trefoil]]
[[Category: Jelly-roll]]
[[Category: Toxin]]

Latest revision as of 09:54, 7 February 2024

THE HC FRAGMENT OF TETANUS TOXIN COMPLEXED WITH GALACTOSETHE HC FRAGMENT OF TETANUS TOXIN COMPLEXED WITH GALACTOSE

Structural highlights

1diw is a 1 chain structure with sequence from Clostridium tetani. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TETX_CLOTE Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-|-Phe-77' bond of synaptobrevin-2.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1diw, resolution 2.00Å

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OCA
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