1dgf: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1dgf.png|left|200px]]
-{{STRUCTURE_1dgf|  PDB=1dgf  |  SCENE=  }}
+==HUMAN ERYTHROCYTE CATALASE==
+<StructureSection load='1dgf' size='340' side='right'caption='[[1dgf]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
-===HUMAN ERYTHROCYTE CATALASE===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1dgf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DGF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DGF FirstGlance]. <br>
-{{ABSTRACT_PUBMED_10656833}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dgf OCA], [https://pdbe.org/1dgf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dgf RCSB], [https://www.ebi.ac.uk/pdbsum/1dgf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dgf ProSAT]</span></td></tr>
-[[1dgf]] is a 4 chain structure of [[Catalase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DGF OCA].
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/CATA_HUMAN CATA_HUMAN] Defects in CAT are the cause of acatalasemia (ACATLAS) [MIM:[https://omim.org/entry/614097 614097]. A metabolic disorder characterized by absence of catalase activity in red cells and is often associated with ulcerating oral lesions.<ref>PMID:2308162</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/CATA_HUMAN CATA_HUMAN] Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells.<ref>PMID:7882369</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dg/1dgf_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dgf ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Catalase|Catalase]]
+*[[Catalase 3D structures|Catalase 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:010656833</ref><references group="xtra"/>
+__TOC__
-[[Category: Catalase]]
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Arvai, A S.]]
+[[Category: Large Structures]]
-[[Category: Bourne, Y.]]
+[[Category: Arvai AS]]
-[[Category: Putnam, C D.]]
+[[Category: Bourne Y]]
-[[Category: Tainer, J A.]]
+[[Category: Putnam CD]]
-[[Category: Catalase]]
+[[Category: Tainer JA]]
-[[Category: Heme]]
-[[Category: Hydrogen peroxide]]
-[[Category: Nadph]]
-[[Category: Oxidoreductase]]