1dg7: Difference between revisions

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{{Seed}}
[[Image:1dg7.png|left|200px]]


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==DIHYDROFOLATE REDUCTASE OF MYCOBACTERIUM TUBERCULOSIS COMPLEXED WITH NADPH AND 4-BROMO WR99210==
The line below this paragraph, containing "STRUCTURE_1dg7", creates the "Structure Box" on the page.
<StructureSection load='1dg7' size='340' side='right'caption='[[1dg7]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1dg7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DG7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DG7 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=WRB:1-[3-(4-BROMO-PHENOXY)-PROPOXY]-6,6-DIMETHYL-1.6-DIHYDRO-[1,3,5]TRIAZINE-2,4-DIAMINE'>WRB</scene></td></tr>
{{STRUCTURE_1dg7| PDB=1dg7 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dg7 OCA], [https://pdbe.org/1dg7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dg7 RCSB], [https://www.ebi.ac.uk/pdbsum/1dg7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dg7 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DYR_MYCTU DYR_MYCTU] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dg/1dg7_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dg7 ConSurf].
<div style="clear:both"></div>


===DIHYDROFOLATE REDUCTASE OF MYCOBACTERIUM TUBERCULOSIS COMPLEXED WITH NADPH AND 4-BROMO WR99210===
==See Also==
 
*[[Art:DHFR: A target for TB drugs|Art:DHFR: A target for TB drugs]]
 
*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_10623528}}
 
==About this Structure==
1DG7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DG7 OCA].
 
==Reference==
Three-dimensional structure of M. tuberculosis dihydrofolate reductase reveals opportunities for the design of novel tuberculosis drugs., Li R, Sirawaraporn R, Chitnumsub P, Sirawaraporn W, Wooden J, Athappilly F, Turley S, Hol WG, J Mol Biol. 2000 Jan 14;295(2):307-23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10623528 10623528]
[[Category: Dihydrofolate reductase]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Single protein]]
[[Category: Athappilly F]]
[[Category: Athappilly, F.]]
[[Category: Chitnumsub P]]
[[Category: Chitnumsub, P.]]
[[Category: Hol WG]]
[[Category: Hol, W G.]]
[[Category: Li R]]
[[Category: Li, R.]]
[[Category: Sirawaraporn R]]
[[Category: Sirawaraporn, R.]]
[[Category: Sirawaraporn W]]
[[Category: Sirawaraporn, W.]]
[[Category: Turley S]]
[[Category: Turley, S.]]
[[Category: Wooden J]]
[[Category: Wooden, J.]]
[[Category: Anti-malaria agent]]
[[Category: Dihydrofolate reductase]]
[[Category: Folateanalog]]
[[Category: Nicotinamide adenine dinucleotide]]
[[Category: Rossmann fold]]
[[Category: Structure-based inhibitor design]]
[[Category: Tuberculosis]]
[[Category: Wr99210]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:02:03 2008''

Latest revision as of 09:53, 7 February 2024

DIHYDROFOLATE REDUCTASE OF MYCOBACTERIUM TUBERCULOSIS COMPLEXED WITH NADPH AND 4-BROMO WR99210DIHYDROFOLATE REDUCTASE OF MYCOBACTERIUM TUBERCULOSIS COMPLEXED WITH NADPH AND 4-BROMO WR99210

Structural highlights

1dg7 is a 1 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.8Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DYR_MYCTU Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1dg7, resolution 1.80Å

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