1dfq: Difference between revisions

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[[Image:1dfq.png|left|200px]]


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==THE HC FRAGMENT OF TETANUS TOXIN COMPLEXED WITH SIALIC ACID==
The line below this paragraph, containing "STRUCTURE_1dfq", creates the "Structure Box" on the page.
<StructureSection load='1dfq' size='340' side='right'caption='[[1dfq]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1dfq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DFQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DFQ FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SLB:5-N-ACETYL-BETA-D-NEURAMINIC+ACID'>SLB</scene></td></tr>
{{STRUCTURE_1dfq| PDB=1dfq |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dfq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dfq OCA], [https://pdbe.org/1dfq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dfq RCSB], [https://www.ebi.ac.uk/pdbsum/1dfq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dfq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TETX_CLOTE TETX_CLOTE] Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-|-Phe-77' bond of synaptobrevin-2.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/df/1dfq_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dfq ConSurf].
<div style="clear:both"></div>


===THE HC FRAGMENT OF TETANUS TOXIN COMPLEXED WITH SIALIC ACID===
==See Also==
 
*[[Tetanus toxin|Tetanus toxin]]
 
__TOC__
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{{ABSTRACT_PUBMED_10722735}}
 
==About this Structure==
1DFQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DFQ OCA].
 
==Reference==
The structures of the H(C) fragment of tetanus toxin with carbohydrate subunit complexes provide insight into ganglioside binding., Emsley P, Fotinou C, Black I, Fairweather NF, Charles IG, Watts C, Hewitt E, Isaacs NW, J Biol Chem. 2000 Mar 24;275(12):8889-94. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10722735 10722735]
[[Category: Clostridium tetani]]
[[Category: Clostridium tetani]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Tentoxilysin]]
[[Category: Black I]]
[[Category: Black, I.]]
[[Category: Charles IG]]
[[Category: Charles, I G.]]
[[Category: Emsley P]]
[[Category: Emsley, P.]]
[[Category: Fairweather NF]]
[[Category: Fairweather, N F.]]
[[Category: Fotinou C]]
[[Category: Fotinou, C.]]
[[Category: Hewitt E]]
[[Category: Hewitt, E.]]
[[Category: Isaacs NW]]
[[Category: Isaacs, N W.]]
[[Category: Watts C]]
[[Category: Watts, C.]]
[[Category: Beta trefoil]]
[[Category: Carbohydrate]]
[[Category: Jelly-roll]]
[[Category: Toxin]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:00:34 2008''

Latest revision as of 09:53, 7 February 2024

THE HC FRAGMENT OF TETANUS TOXIN COMPLEXED WITH SIALIC ACIDTHE HC FRAGMENT OF TETANUS TOXIN COMPLEXED WITH SIALIC ACID

Structural highlights

1dfq is a 1 chain structure with sequence from Clostridium tetani. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.6Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TETX_CLOTE Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-|-Phe-77' bond of synaptobrevin-2.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1dfq, resolution 2.60Å

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