1dev: Difference between revisions

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OCA

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-[[Image:1dev.gif|left|200px]]<br />
-<applet load="1dev" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="1dev, resolution 2.2&Aring;" />
-'''CRYSTAL STRUCTURE OF SMAD2 MH2 DOMAIN BOUND TO THE SMAD-BINDING DOMAIN OF SARA'''<br />
-==Overview==
+==CRYSTAL STRUCTURE OF SMAD2 MH2 DOMAIN BOUND TO THE SMAD-BINDING DOMAIN OF SARA==
-The Smad proteins mediate transforming growth factor-beta (TGFbeta), signaling from the transmembrane serine-threonine receptor kinases to the, nucleus. The Smad anchor for receptor activation (SARA) recruits Smad2 to, the TGFbeta receptors for phosphorylation. The crystal structure of a, Smad2 MH2 domain in complex with the Smad-binding domain (SBD) of SARA has, been determined at 2.2 angstrom resolution. SARA SBD, in an extended, conformation comprising a rigid coil, an alpha helix, and a beta strand, interacts with the beta sheet and the three-helix bundle of Smad2., Recognition between the SARA rigid coil and the Smad2 beta sheet is, essential for specificity, whereas interactions between the SARA beta, strand and the Smad2 three-helix bundle contribute significantly to, binding affinity. Comparison of the structures between Smad2 and a, comediator Smad suggests a model for how receptor-regulated Smads are, recognized by the type I receptors.
+<StructureSection load='1dev' size='340' side='right'caption='[[1dev]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
+== Structural highlights ==
-==Disease==
+<table><tr><td colspan='2'>[[1dev]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DEV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DEV FirstGlance]. <br>
-Known diseases associated with this structure: Anderson disease OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=607690 607690]], Chylomicron retention disease OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=607690 607690]], Chylomicron retention disease with Marinesco-Sjogren syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=607690 607690]], Mowat-Wilson syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=605802 605802]]
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dev FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dev OCA], [https://pdbe.org/1dev PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dev RCSB], [https://www.ebi.ac.uk/pdbsum/1dev PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dev ProSAT]</span></td></tr>
-==About this Structure==
+</table>
-DEV is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1DEV OCA].
+== Function ==
+[https://www.uniprot.org/uniprot/SMAD2_HUMAN SMAD2_HUMAN] Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.<ref>PMID:9892009</ref> <ref>PMID:16751101</ref> <ref>PMID:17327236</ref> <ref>PMID:16862174</ref> <ref>PMID:19289081</ref>
-==Reference==
+== Evolutionary Conservation ==
-Structural basis of Smad2 recognition by the Smad anchor for receptor activation., Wu G, Chen YG, Ozdamar B, Gyuricza CA, Chong PA, Wrana JL, Massague J, Shi Y, Science. 2000 Jan 7;287(5450):92-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10615055 10615055]
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/de/1dev_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dev ConSurf].
+<div style="clear:both"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Protein complex]]
+[[Category: Large Structures]]
-[[Category: Shi, Y.]]
+[[Category: Shi Y]]
-[[Category: Wu, G.]]
+[[Category: Wu G]]
-[[Category: beta sheet]]
-[[Category: three-helix bundle]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 16:31:40 2007''