1dcv: Difference between revisions

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[[Image:1dcv.gif|left|200px]]


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==B-DNA DECAMER WITH CENTRAL TA DINUCLEOTIDE==
The line below this paragraph, containing "STRUCTURE_1dcv", creates the "Structure Box" on the page.
<StructureSection load='1dcv' size='340' side='right'caption='[[1dcv]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1dcv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DCV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DCV FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dcv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dcv OCA], [https://pdbe.org/1dcv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dcv RCSB], [https://www.ebi.ac.uk/pdbsum/1dcv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dcv ProSAT]</span></td></tr>
{{STRUCTURE_1dcv|  PDB=1dcv  |  SCENE= }}
</table>
 
__TOC__
'''B-DNA DECAMER WITH CENTRAL TA DINUCLEOTIDE'''
</StructureSection>
 
[[Category: Large Structures]]
 
[[Category: Eichman BF]]
==Overview==
[[Category: Ho PS]]
Holliday junctions are important structural intermediates in recombination, viral integration, and DNA repair. We present here the single-crystal structure of the inverted repeat sequence d(CCGGTACCGG) as a Holliday junction at the nominal resolution of 2. 1 A. Unlike the previous crystal structures, this DNA junction has B-DNA arms with all standard Watson-Crick base pairs; it therefore represents the intermediate proposed by Holliday as being involved in homologous recombination. The junction is in the stacked-X conformation, with two interconnected duplexes formed by coaxially stacked arms, and is crossed at an angle of 41.4 degrees as a right-handed X. A sequence comparison with previous B-DNA and junction crystal structures shows that an ACC trinucleotide forms the core of a stable junction in this system. The 3'-C x G base pair of this ACC core forms direct and water-mediated hydrogen bonds to the phosphates at the crossover strands. Interactions within this core define the conformation of the Holliday junction, including the angle relating the stacked duplexes and how the base pairs are stacked in the stable form of the junction.
[[Category: Mooers BHM]]
 
[[Category: Vargason JM]]
==About this Structure==
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DCV OCA].  
 
==Reference==
The Holliday junction in an inverted repeat DNA sequence: sequence effects on the structure of four-way junctions., Eichman BF, Vargason JM, Mooers BH, Ho PS, Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):3971-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10760268 10760268]
[[Category: Eichman, B F.]]
[[Category: Ho, P S.]]
[[Category: Mooers, B H.M.]]
[[Category: Vargason, J M.]]
[[Category: Central ta dinucleotide]]
[[Category: Deoxyribonucleic acid]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 13:42:18 2008''

Latest revision as of 09:52, 7 February 2024

B-DNA DECAMER WITH CENTRAL TA DINUCLEOTIDEB-DNA DECAMER WITH CENTRAL TA DINUCLEOTIDE

Structural highlights

1dcv is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.5Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

1dcv, resolution 2.50Å

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