1dco: Difference between revisions

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OCA

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-{{Seed}}
-[[Image:1dco.png|left|200px]]
-<!--
+==DCOH, A BIFUNCTIONAL PROTEIN-BINDING TRANSCRIPTIONAL COACTIVATOR==
-The line below this paragraph, containing "STRUCTURE_1dco", creates the "Structure Box" on the page.
+<StructureSection load='1dco' size='340' side='right'caption='[[1dco]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1dco]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DCO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DCO FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dco OCA], [https://pdbe.org/1dco PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dco RCSB], [https://www.ebi.ac.uk/pdbsum/1dco PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dco ProSAT]</span></td></tr>
-{{STRUCTURE_1dco|  PDB=1dco  |  SCENE=  }}
+</table>
+== Function ==
-===DCOH, A BIFUNCTIONAL PROTEIN-BINDING TRANSCRIPTIONAL COACTIVATOR===
+[https://www.uniprot.org/uniprot/PHS_RAT PHS_RAT] Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity.<ref>PMID:1763325</ref> <ref>PMID:8444860</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
-<!--
+Check<jmol>
-The line below this paragraph, {{ABSTRACT_PUBMED_8897596}}, adds the Publication Abstract to the page
+  <jmolCheckbox>
-(as it appears on PubMed at http://www.pubmed.gov), where 8897596 is the PubMed ID number.
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dc/1dco_consurf.spt"</scriptWhenChecked>
--->
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-{{ABSTRACT_PUBMED_8897596}}
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
-==About this Structure==
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dco ConSurf].
-DCO is a 8 chains structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DCO OCA].
+<div style="clear:both"></div>
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:8897596</ref><references group="xtra"/>
+__TOC__
-[[Category: 4a-hydroxytetrahydrobiopterin dehydratase]]
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Rattus norvegicus]]
-[[Category: Alber, T.]]
+[[Category: Alber T]]
-[[Category: Cronk, J D.]]
+[[Category: Cronk JD]]
-[[Category: Endrizzi, J A.]]
+[[Category: Endrizzi JA]]
-[[Category: 4a-carbinolamine dehydratase]]
-[[Category: Dehydratase]]
-[[Category: Dimerization cofactor]]
-[[Category: Transcriptional stimulator]]
-[[Category: Transregulator of homeodomain protein]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 15:24:52 2009''