1d92: Difference between revisions

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[[Image:1d92.gif|left|200px]]


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==REFINED CRYSTAL STRUCTURE OF AN OCTANUCLEOTIDE DUPLEX WITH G.T MISMATCHED BASE-PAIRS==
The line below this paragraph, containing "STRUCTURE_1d92", creates the "Structure Box" on the page.
<StructureSection load='1d92' size='340' side='right'caption='[[1d92]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1d92]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D92 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1D92 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1d92 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d92 OCA], [https://pdbe.org/1d92 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1d92 RCSB], [https://www.ebi.ac.uk/pdbsum/1d92 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1d92 ProSAT]</span></td></tr>
{{STRUCTURE_1d92|  PDB=1d92  |  SCENE= }}
</table>
 
__TOC__
'''REFINED CRYSTAL STRUCTURE OF AN OCTANUCLEOTIDE DUPLEX WITH G.T MISMATCHED BASE-PAIRS'''
</StructureSection>
 
[[Category: Large Structures]]
 
[[Category: Brown T]]
==Overview==
[[Category: Hunter WN]]
Single crystal X-ray diffraction techniques have been used to determine the structure of the DNA octamer d(G-G-G-G-C-T-C-C) at a resolution of 2.25 A. The asymmetric unit consists of two strands coiled about each other to produce an A-type DNA helix. The double helix contains six G . C Watson-Crick base-pairs and two G . T mismatched base-pairs. The mismatches adopt a "wobble" type structure in which both bases retain their major tautomer forms. The double helix is able to accommodate this G . T pairing with little distortion of the overall helical conformation. Crystals of this octamer melt at a substantially lower temperature than do those of a related octamer also containing two G . T base-pairs. We attribute this destabilization to disruption of the hydration network around the mismatch site combined with changes in intermolecular packing. Full details are given of conformational parameters, base stacking, intermolecular contacts and hydration involving 52 solvent molecules.
[[Category: Kennard O]]
 
[[Category: Kneale G]]
==About this Structure==
[[Category: Rabinovich D]]
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D92 OCA].  
 
==Reference==
Refined crystal structure of an octanucleotide duplex with G . T mismatched base-pairs., Hunter WN, Kneale G, Brown T, Rabinovich D, Kennard O, J Mol Biol. 1986 Aug 20;190(4):605-18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/3783714 3783714]
[[Category: Brown, T.]]
[[Category: Hunter, W N.]]
[[Category: Kennard, O.]]
[[Category: Kneale, G.]]
[[Category: Rabinovich, D.]]
[[Category: A-dna]]
[[Category: Double helix]]
[[Category: Mismatched]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 13:35:19 2008''

Latest revision as of 09:50, 7 February 2024

REFINED CRYSTAL STRUCTURE OF AN OCTANUCLEOTIDE DUPLEX WITH G.T MISMATCHED BASE-PAIRSREFINED CRYSTAL STRUCTURE OF AN OCTANUCLEOTIDE DUPLEX WITH G.T MISMATCHED BASE-PAIRS

Structural highlights

1d92 is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.25Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

1d92, resolution 2.25Å

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