1d8a: Difference between revisions

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-[[Image:1d8a.jpg|left|200px]]
- {{Structure
+==E. COLI ENOYL REDUCTASE/NAD+/TRICLOSAN COMPLEX==
-|PDB= 1d8a |SIZE=350|CAPTION= <scene name='initialview01'>1d8a</scene>, resolution 2.2&Aring;
+<StructureSection load='1d8a' size='340' side='right'caption='[[1d8a]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND= <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene> and <scene name='pdbligand=TCL:TRICLOSAN'>TCL</scene>
+<table><tr><td colspan='2'>[[1d8a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D8A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1D8A FirstGlance]. <br>
-|ACTIVITY= [http://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9]
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-|GENE=
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=TCL:TRICLOSAN'>TCL</scene></td></tr>
-}}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1d8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d8a OCA], [https://pdbe.org/1d8a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1d8a RCSB], [https://www.ebi.ac.uk/pdbsum/1d8a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1d8a ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/FABI_ECOLI FABI_ECOLI] Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism and in the biotin biosynthesis.<ref>PMID:8119879</ref> <ref>PMID:7592873</ref> <ref>PMID:20693992</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d8/1d8a_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1d8a ConSurf].
+<div style="clear:both"></div>
-'''E. COLI ENOYL REDUCTASE/NAD+/TRICLOSAN COMPLEX'''
+==See Also==
+*[[Enoyl-Acyl-Carrier Protein Reductase 3D structures|Enoyl-Acyl-Carrier Protein Reductase 3D structures]]
+== References ==
-==About this Structure==
+<references/>
-D8A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D8A OCA].
+__TOC__
+</StructureSection>
-==Reference==
-Molecular basis of triclosan activity., Levy CW, Roujeinikova A, Sedelnikova S, Baker PJ, Stuitje AR, Slabas AR, Rice DW, Rafferty JB, Nature. 1999 Apr 1;398(6726):383-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10201369 10201369]
-[[Category: Enoyl-[acyl-carrier-protein] reductase (NADH)]]
 [[Category: Escherichia coli]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Baker, P J.]]
+[[Category: Baker PJ]]
-[[Category: Levy, C W.]]
+[[Category: Levy CW]]
-[[Category: Rafferty, J B.]]
+[[Category: Rafferty JB]]
-[[Category: Rice, D W.]]
+[[Category: Rice DW]]
-[[Category: Roujeinikova, A.]]
+[[Category: Roujeinikova A]]
-[[Category: Sedelnikova, S.]]
+[[Category: Sedelnikova S]]
-[[Category: Slabas, A R.]]
+[[Category: Slabas AR]]
-[[Category: Stuitje, A R.]]
+[[Category: Stuitje AR]]
-[[Category: NAD]]
-[[Category: TCL]]
-[[Category: e. coli enoyl reductase]]
-[[Category: triclosan]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:34:24 2008''