1d64: Difference between revisions

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OCA

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-[[Image:1d64.gif|left|200px]]<br /><applet load="1d64" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="1d64, resolution 2.100&Aring;" />
-'''CRYSTAL STRUCTURE OF A PENTAMIDINE-OLIGONUCLEOTIDE COMPLEX: IMPLICATIONS FOR DNA-BINDING PROPERTIES'''<br />
-==Overview==
+==CRYSTAL STRUCTURE OF A PENTAMIDINE-OLIGONUCLEOTIDE COMPLEX: IMPLICATIONS FOR DNA-BINDING PROPERTIES==
-The crystal structure of the complex formed between the dodecanucleotide, d(CGCGAATTCGCG)2 and the drug pentamidine, which is active against the, Pneumocystis carinii pathogen in AIDS patients, has been determined to a, resolution of 2.1 A and an R-factor of 19.4%. Analysis of the structure, has shown the drug to be bound in the 5'-AATT minor groove region of the, duplex, with the amidinium groups H-bonded to adenine N3 atoms in an, interstrand manner. The drug molecule adopts an extended conformation, and, the immediate binding site spans four base pairs. Structural details of, the drug-DNA interactions are discussed, and comparison is made with the, dodecamer complex of the structurally similar berenil ligand.
+<StructureSection load='1d64' size='340' side='right'caption='[[1d64]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
+== Structural highlights ==
-==About this Structure==
+<table><tr><td colspan='2'>[[1d64]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D64 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1D64 FirstGlance]. <br>
-D64 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with PNT as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1D64 OCA].
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PNT:1,5-BIS(4-AMIDINOPHENOXY)PENTANE'>PNT</scene></td></tr>
-==Reference==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1d64 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d64 OCA], [https://pdbe.org/1d64 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1d64 RCSB], [https://www.ebi.ac.uk/pdbsum/1d64 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1d64 ProSAT]</span></td></tr>
-Crystal structure of a pentamidine-oligonucleotide complex: implications for DNA-binding properties., Edwards KJ, Jenkins TC, Neidle S, Biochemistry. 1992 Aug 11;31(31):7104-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=1643044 1643044]
+</table>
-[[Category: Protein complex]]
+__TOC__
-[[Category: Edwards, K.J.]]
+</StructureSection>
-[[Category: Jenkins, T.C.]]
+[[Category: Large Structures]]
-[[Category: Neidle, S.]]
+[[Category: Edwards KJ]]
-[[Category: PNT]]
+[[Category: Jenkins TC]]
-[[Category: b-dna]]
+[[Category: Neidle S]]
-[[Category: complexed with drug]]
-[[Category: double helix]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 02:34:42 2007''