1d5f: Difference between revisions

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-{{Seed}}
-[[Image:1d5f.png|left|200px]]
-<!--
+==STRUCTURE OF E6AP: INSIGHTS INTO UBIQUITINATION PATHWAY==
-The line below this paragraph, containing "STRUCTURE_1d5f", creates the "Structure Box" on the page.
+<StructureSection load='1d5f' size='340' side='right'caption='[[1d5f]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1d5f]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D5F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1D5F FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1d5f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d5f OCA], [https://pdbe.org/1d5f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1d5f RCSB], [https://www.ebi.ac.uk/pdbsum/1d5f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1d5f ProSAT]</span></td></tr>
-{{STRUCTURE_1d5f|  PDB=1d5f  |  SCENE=  }}
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/UBE3A_HUMAN UBE3A_HUMAN] Defects in UBE3A are a cause of Angelman syndrome (AS) [MIM:[https://omim.org/entry/105830 105830]; also known as 'happy puppet syndrome'. AS is characterized by features of severe motor and intellectual retardation, microcephaly, ataxia, frequent jerky limb movements and flapping of the arms and hands, hypotonia, hyperactivity, hypopigmentation, seizures, absence of speech, frequent smiling and episodes of paroxysmal laughter, and an unusual facies characterized by macrostomia, a large mandible and open-mouthed expression, a great propensity for protruding the tongue ('tongue thrusting'), and an occipital groove.<ref>PMID:10508479</ref> <ref>PMID:9585605</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/UBE3A_HUMAN UBE3A_HUMAN] E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. Several substrates have been identified including the RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B. Catalyzes the high-risk human papilloma virus E6-mediated ubiquitination of p53/TP53, contributing to the neoplastic progression of cells infected by these viruses. Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins. Finally, UBE3A also promotes its own degradation in vivo.<ref>PMID:10373495</ref> <ref>PMID:19325566</ref> <ref>PMID:19233847</ref> <ref>PMID:19204938</ref> <ref>PMID:19591933</ref> <ref>PMID:22645313</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d5/1d5f_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1d5f ConSurf].
+<div style="clear:both"></div>
-===STRUCTURE OF AN E6AP-UBCH7 COMPLEX: INSIGHTS INTO THE UBIQUITINATION PATHWAY===
+==See Also==
+*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_10558980}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 10558980 is the PubMed ID number.
+</StructureSection>
--->
-{{ABSTRACT_PUBMED_10558980}}
-==About this Structure==
-D5F is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D5F OCA].
-==Reference==
-<ref group="xtra">PMID:10558980</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Beaudenon, S.]]
+[[Category: Large Structures]]
-[[Category: Howley, P M.]]
+[[Category: Beaudenon S]]
-[[Category: Huang, L.]]
+[[Category: Howley PM]]
-[[Category: Huibregtse, J M.]]
+[[Category: Huang L]]
-[[Category: Kinnucan, E.]]
+[[Category: Huibregtse JM]]
-[[Category: Pavletich, N P.]]
+[[Category: Kinnucan E]]
-[[Category: Wang, G.]]
+[[Category: Pavletich NP]]
-[[Category: Bilobal structure]]
+[[Category: Wang G]]
-[[Category: E3 ligase]]
-[[Category: Elongated shape]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 21:43:14 2009''