|
|
(11 intermediate revisions by the same user not shown) |
Line 1: |
Line 1: |
| [[Image:1d53.gif|left|200px]]
| |
|
| |
|
| {{Structure
| | ==CRYSTAL STRUCTURE AT 1.5 ANGSTROMS RESOLUTION OF D(CGCICICG), AN OCTANUCLEOTIDE CONTAINING INOSINE, AND ITS COMPARISON WITH D(CGCG) AND D(CGCGCG) STRUCTURES== |
| |PDB= 1d53 |SIZE=350|CAPTION= <scene name='initialview01'>1d53</scene>, resolution 1.500Å
| | <StructureSection load='1d53' size='340' side='right'caption='[[1d53]], [[Resolution|resolution]] 1.50Å' scene=''> |
| |SITE=
| | == Structural highlights == |
| |LIGAND= <scene name='pdbligand=DC:2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE'>DG</scene>
| | <table><tr><td colspan='2'>[[1d53]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D53 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1D53 FirstGlance]. <br> |
| |ACTIVITY=
| | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> |
| |GENE=
| | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1d53 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d53 OCA], [https://pdbe.org/1d53 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1d53 RCSB], [https://www.ebi.ac.uk/pdbsum/1d53 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1d53 ProSAT]</span></td></tr> |
| |DOMAIN=
| | </table> |
| |RELATEDENTRY=
| | __TOC__ |
| |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1d53 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d53 OCA], [http://www.ebi.ac.uk/pdbsum/1d53 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1d53 RCSB]</span>
| | </StructureSection> |
| }}
| | [[Category: Large Structures]] |
| | | [[Category: Andrews LC]] |
| '''CRYSTAL STRUCTURE AT 1.5 ANGSTROMS RESOLUTION OF D(CGCICICG), AN OCTANUCLEOTIDE CONTAINING INOSINE, AND ITS COMPARISON WITH D(CGCG) AND D(CGCGCG) STRUCTURES'''
| | [[Category: Harrison RW]] |
| | | [[Category: Kumar VD]] |
| | | [[Category: Weber IT]] |
| ==Overview==
| |
| The octadeoxyribonucleotide d(CGCICICG) has been crystallized in space group P(6)5(22) with unit cell dimensions of a = b = 31.0 A and c = 43.7 A, and X-ray diffraction data have been collected to 1.5-A resolution. Precession photographs and the self-Patterson function indicate that 12 base pairs of Z-conformation DNA stack along the c-axis, and the double helices pack in a hexagonal array similar to that seen in other crystals of Z-DNA. The structure has been solved by both Patterson deconvolution and molecular replacement methods and refined in space group P(6)5 to an R factor of 0.225 using 2503 unique reflections greater than 3.0 sigma (F). Comparison of the molecules within the hexagonal lattice with highly refined crystal structures of other Z-DNA reveals only minor conformational differences, most notably in the pucker of the deoxyribose of the purine residues. The DNA has multiple occupancy of C:I and C:G base pairs, and C:I base pairs adopt a conformation similar to that of C:G base pairs.
| |
| | |
| ==About this Structure==
| |
| 1D53 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D53 OCA].
| |
| | |
| ==Reference==
| |
| Crystal structure at 1.5-A resolution of d(CGCICICG), an octanucleotide containing inosine, and its comparison with d(CGCG) and d(CGCGCG) structures., Kumar VD, Harrison RW, Andrews LC, Weber IT, Biochemistry. 1992 Feb 11;31(5):1541-50. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1737011 1737011]
| |
| [[Category: Protein complex]] | |
| [[Category: Andrews, L C.]] | |
| [[Category: Harrison, R W.]] | |
| [[Category: Kumar, V D.]] | |
| [[Category: Weber, I T.]] | |
| [[Category: double helix]]
| |
| [[Category: z-dna]]
| |
| | |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:34:49 2008''
| |