1d53: Difference between revisions

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[[Image:1d53.gif|left|200px]]


{{Structure
==CRYSTAL STRUCTURE AT 1.5 ANGSTROMS RESOLUTION OF D(CGCICICG), AN OCTANUCLEOTIDE CONTAINING INOSINE, AND ITS COMPARISON WITH D(CGCG) AND D(CGCGCG) STRUCTURES==
|PDB= 1d53 |SIZE=350|CAPTION= <scene name='initialview01'>1d53</scene>, resolution 1.500&Aring;
<StructureSection load='1d53' size='340' side='right'caption='[[1d53]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>
<table><tr><td colspan='2'>[[1d53]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D53 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1D53 FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
|GENE=  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1d53 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d53 OCA], [https://pdbe.org/1d53 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1d53 RCSB], [https://www.ebi.ac.uk/pdbsum/1d53 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1d53 ProSAT]</span></td></tr>
|DOMAIN=
</table>
|RELATEDENTRY=
__TOC__
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1d53 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d53 OCA], [http://www.ebi.ac.uk/pdbsum/1d53 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1d53 RCSB]</span>
</StructureSection>
}}
[[Category: Large Structures]]
 
[[Category: Andrews LC]]
'''CRYSTAL STRUCTURE AT 1.5 ANGSTROMS RESOLUTION OF D(CGCICICG), AN OCTANUCLEOTIDE CONTAINING INOSINE, AND ITS COMPARISON WITH D(CGCG) AND D(CGCGCG) STRUCTURES'''
[[Category: Harrison RW]]
 
[[Category: Kumar VD]]
 
[[Category: Weber IT]]
==Overview==
The octadeoxyribonucleotide d(CGCICICG) has been crystallized in space group P(6)5(22) with unit cell dimensions of a = b = 31.0 A and c = 43.7 A, and X-ray diffraction data have been collected to 1.5-A resolution. Precession photographs and the self-Patterson function indicate that 12 base pairs of Z-conformation DNA stack along the c-axis, and the double helices pack in a hexagonal array similar to that seen in other crystals of Z-DNA. The structure has been solved by both Patterson deconvolution and molecular replacement methods and refined in space group P(6)5 to an R factor of 0.225 using 2503 unique reflections greater than 3.0 sigma (F). Comparison of the molecules within the hexagonal lattice with highly refined crystal structures of other Z-DNA reveals only minor conformational differences, most notably in the pucker of the deoxyribose of the purine residues. The DNA has multiple occupancy of C:I and C:G base pairs, and C:I base pairs adopt a conformation similar to that of C:G base pairs.
 
==About this Structure==
1D53 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D53 OCA].
 
==Reference==
Crystal structure at 1.5-A resolution of d(CGCICICG), an octanucleotide containing inosine, and its comparison with d(CGCG) and d(CGCGCG) structures., Kumar VD, Harrison RW, Andrews LC, Weber IT, Biochemistry. 1992 Feb 11;31(5):1541-50. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1737011 1737011]
[[Category: Protein complex]]
[[Category: Andrews, L C.]]
[[Category: Harrison, R W.]]
[[Category: Kumar, V D.]]
[[Category: Weber, I T.]]
[[Category: double helix]]
[[Category: z-dna]]
 
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