1cw4: Difference between revisions

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-[[Image:1cw4.png|left|200px]]
-{{STRUCTURE_1cw4|  PDB=1cw4  |  SCENE=  }}
+==CRYSTAL STRUCTURE OF K230M ISOCITRATE DEHYDROGENASE IN COMPLEX WITH ALPHA-KETOGLUTARATE==
+<StructureSection load='1cw4' size='340' side='right'caption='[[1cw4]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-===CRYSTAL STRUCTURE OF K230M ISOCITRATE DEHYDROGENASE IN COMPLEX WITH ALPHA-KETOGLUTARATE===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1cw4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CW4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CW4 FirstGlance]. <br>
-{{ABSTRACT_PUBMED_10623532}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cw4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cw4 OCA], [https://pdbe.org/1cw4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cw4 RCSB], [https://www.ebi.ac.uk/pdbsum/1cw4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cw4 ProSAT]</span></td></tr>
-[[1cw4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CW4 OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/IDH_ECOLI IDH_ECOLI]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cw/1cw4_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cw4 ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Ferguson sandbox 1|Ferguson sandbox 1]]
+*[[Isocitrate dehydrogenase 3D structures|Isocitrate dehydrogenase 3D structures]]
-*[[Isocitrate dehydrogenase|Isocitrate dehydrogenase]]
+__TOC__
+</StructureSection>
-==Reference==
-<ref group="xtra">PMID:010623532</ref><references group="xtra"/>
 [[Category: Escherichia coli]]
-[[Category: Finer-Moore, J.]]
+[[Category: Large Structures]]
-[[Category: Stroud, M R.]]
+[[Category: Finer-Moore J]]
-[[Category: Isocitrate dehydrogenase]]
+[[Category: Stroud MR]]
-[[Category: Mutant]]
-[[Category: Oxidoreductase]]