1col: Difference between revisions

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[[Image:1col.png|left|200px]]


{{STRUCTURE_1col|  PDB=1col  |  SCENE=  }}
==REFINED STRUCTURE OF THE PORE-FORMING DOMAIN OF COLICIN A AT 2.4 ANGSTROMS RESOLUTION==
 
<StructureSection load='1col' size='340' side='right'caption='[[1col]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
===REFINED STRUCTURE OF THE PORE-FORMING DOMAIN OF COLICIN A AT 2.4 ANGSTROMS RESOLUTION===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1col]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1COL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1COL FirstGlance]. <br>
{{ABSTRACT_PUBMED_1373773}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1col FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1col OCA], [https://pdbe.org/1col PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1col RCSB], [https://www.ebi.ac.uk/pdbsum/1col PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1col ProSAT]</span></td></tr>
==About this Structure==
</table>
[[1col]] is a 2 chain structure of [[Colicin]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1COL OCA].  
== Function ==
[https://www.uniprot.org/uniprot/CEA_ECOLX CEA_ECOLX] This colicin is a channel-forming colicin. This class of transmembrane toxins depolarize the cytoplasmic membrane, leading to dissipation of cellular energy.<ref>PMID:2434951</ref>  Colicins are polypeptide toxins produced by and active against E.coli and closely related bacteria.<ref>PMID:2434951</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/co/1col_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1col ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Colicin|Colicin]]
*[[Colicin 3D structures|Colicin 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:001373773</ref><ref group="xtra">PMID:011170211</ref><ref group="xtra">PMID:012215419</ref><ref group="xtra">PMID:014695246</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Parker, M W.]]
[[Category: Large Structures]]
[[Category: Pattus, F.]]
[[Category: Parker MW]]
[[Category: Postma, J P.M.]]
[[Category: Pattus F]]
[[Category: Tsernoglou, D.]]
[[Category: Postma JPM]]
[[Category: Tucker, A D.]]
[[Category: Tsernoglou D]]
[[Category: Antibacterial protein]]
[[Category: Tucker AD]]

Latest revision as of 09:44, 7 February 2024

REFINED STRUCTURE OF THE PORE-FORMING DOMAIN OF COLICIN A AT 2.4 ANGSTROMS RESOLUTIONREFINED STRUCTURE OF THE PORE-FORMING DOMAIN OF COLICIN A AT 2.4 ANGSTROMS RESOLUTION

Structural highlights

1col is a 2 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.4Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CEA_ECOLX This colicin is a channel-forming colicin. This class of transmembrane toxins depolarize the cytoplasmic membrane, leading to dissipation of cellular energy.[1] Colicins are polypeptide toxins produced by and active against E.coli and closely related bacteria.[2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Baty D, Knibiehler M, Verheij H, Pattus F, Shire D, Bernadac A, Lazdunski C. Site-directed mutagenesis of the COOH-terminal region of colicin A: effect on secretion and voltage-dependent channel activity. Proc Natl Acad Sci U S A. 1987 Mar;84(5):1152-6. PMID:2434951
  2. ↑ Baty D, Knibiehler M, Verheij H, Pattus F, Shire D, Bernadac A, Lazdunski C. Site-directed mutagenesis of the COOH-terminal region of colicin A: effect on secretion and voltage-dependent channel activity. Proc Natl Acad Sci U S A. 1987 Mar;84(5):1152-6. PMID:2434951

1col, resolution 2.40Å

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