1cka: Difference between revisions

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-[[Image:1cka.png|left|200px]]
-{{STRUCTURE_1cka|  PDB=1cka  |  SCENE=  }}
+==STRUCTURAL BASIS FOR THE SPECIFIC INTERACTION OF LYSINE-CONTAINING PROLINE-RICH PEPTIDES WITH THE N-TERMINAL SH3 DOMAIN OF C-CRK==
+<StructureSection load='1cka' size='340' side='right'caption='[[1cka]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1cka]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CKA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CKA FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cka OCA], [https://pdbe.org/1cka PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cka RCSB], [https://www.ebi.ac.uk/pdbsum/1cka PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cka ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CRK_MOUSE CRK_MOUSE] The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ck/1cka_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cka ConSurf].
+<div style="clear:both"></div>
-===STRUCTURAL BASIS FOR THE SPECIFIC INTERACTION OF LYSINE-CONTAINING PROLINE-RICH PEPTIDES WITH THE N-TERMINAL SH3 DOMAIN OF C-CRK===
+==See Also==
+*[[Adapter molecule crk|Adapter molecule crk]]
-{{ABSTRACT_PUBMED_7735837}}
+*[[Adapter molecule crk 3D structures|Adapter molecule crk 3D structures]]
+__TOC__
-==About this Structure==
+</StructureSection>
-[[1cka]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CKA OCA].
+[[Category: Large Structures]]
-==Reference==
-<ref group="xtra">PMID:007735837</ref><ref group="xtra">PMID:011152127</ref><ref group="xtra">PMID:016446784</ref><references group="xtra"/>
 [[Category: Mus musculus]]
-[[Category: Kuriyan, J.]]
+[[Category: Kuriyan J]]
-[[Category: Wu, X.]]
+[[Category: Wu X]]