1c9h: Difference between revisions

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-[[Image:1c9h.png|left|200px]]
-{{STRUCTURE_1c9h|  PDB=1c9h  |  SCENE=  }}
+==CRYSTAL STRUCTURE OF FKBP12.6 IN COMPLEX WITH RAPAMYCIN==
+<StructureSection load='1c9h' size='340' side='right'caption='[[1c9h]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1c9h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C9H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1C9H FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RAP:RAPAMYCIN+IMMUNOSUPPRESSANT+DRUG'>RAP</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1c9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c9h OCA], [https://pdbe.org/1c9h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1c9h RCSB], [https://www.ebi.ac.uk/pdbsum/1c9h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1c9h ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/FKB1B_HUMAN FKB1B_HUMAN] Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c9/1c9h_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1c9h ConSurf].
+<div style="clear:both"></div>
-===CRYSTAL STRUCTURE OF FKBP12.6 IN COMPLEX WITH RAPAMYCIN===
+==See Also==
+*[[FKBP 3D structures|FKBP 3D structures]]
-{{ABSTRACT_PUBMED_10713512}}
+__TOC__
+</StructureSection>
-==About this Structure==
-[[1c9h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C9H OCA].
-==Reference==
-<ref group="xtra">PMID:010713512</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Carson, M.]]
+[[Category: Large Structures]]
-[[Category: Chodavarapu, C S.]]
+[[Category: Carson M]]
-[[Category: Deivanayagam, C C.S.]]
+[[Category: Chodavarapu CS]]
-[[Category: Narayana, S V.L.]]
+[[Category: Deivanayagam CCS]]
-[[Category: Thotakura, A.]]
+[[Category: Narayana SVL]]
-[[Category: Complex]]
+[[Category: Thotakura A]]
-[[Category: Fkbp12]]
-[[Category: Immune system]]
-[[Category: Rapamycin]]
-[[Category: Ryanodine receptor]]