1c94: Difference between revisions

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==REVERSING THE SEQUENCE OF THE GCN4 LEUCINE ZIPPER DOES NOT AFFECT ITS FOLD.==
==REVERSING THE SEQUENCE OF THE GCN4 LEUCINE ZIPPER DOES NOT AFFECT ITS FOLD.==
<StructureSection load='1c94' size='340' side='right' caption='[[1c94]], [[Resolution|resolution]] 2.08&Aring;' scene=''>
<StructureSection load='1c94' size='340' side='right'caption='[[1c94]], [[Resolution|resolution]] 2.08&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1c94]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C94 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1C94 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1c94]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C94 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1C94 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c94 OCA], [http://pdbe.org/1c94 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1c94 RCSB], [http://www.ebi.ac.uk/pdbsum/1c94 PDBsum]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.08&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1c94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c94 OCA], [https://pdbe.org/1c94 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1c94 RCSB], [https://www.ebi.ac.uk/pdbsum/1c94 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1c94 ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The question of whether a protein whose natural sequence is inverted adopts a stable fold is still under debate. We have determined the 2. 1-A crystal structure of the retro-GCN4 leucine zipper. In contrast to the two-stranded helical coiled-coil GCN4 leucine zipper, the retro-leucine zipper formed a very stable, parallel four-helix bundle, which now lends itself to further structural and functional studies.
The retro-GCN4 leucine zipper sequence forms a stable three-dimensional structure.,Mittl PR, Deillon C, Sargent D, Liu N, Klauser S, Thomas RM, Gutte B, Grutter MG Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2562-6. PMID:10716989<ref>PMID:10716989</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1c94" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Gcn4|Gcn4]]
*[[Gcn4 3D Structures|Gcn4 3D Structures]]
== References ==
*[[Gnc4 3D Structures|Gnc4 3D Structures]]
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Deillon, C A]]
[[Category: Large Structures]]
[[Category: Gruetter, M G]]
[[Category: Deillon CA]]
[[Category: Gutte, B]]
[[Category: Gruetter MG]]
[[Category: Klauser, S]]
[[Category: Gutte B]]
[[Category: Liu, N]]
[[Category: Klauser S]]
[[Category: Mittl, P R.E]]
[[Category: Liu N]]
[[Category: Sargent, D]]
[[Category: Mittl PRE]]
[[Category: Thomas, R M]]
[[Category: Sargent D]]
[[Category: 4-alpha-helix-bundle]]
[[Category: Thomas RM]]
[[Category: Gene regulation]]
[[Category: Peptide synthesis]]
[[Category: Retro-coiled coil]]

Latest revision as of 09:41, 7 February 2024

REVERSING THE SEQUENCE OF THE GCN4 LEUCINE ZIPPER DOES NOT AFFECT ITS FOLD.REVERSING THE SEQUENCE OF THE GCN4 LEUCINE ZIPPER DOES NOT AFFECT ITS FOLD.

Structural highlights

1c94 is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.08Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

See Also

1c94, resolution 2.08Å

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