1bl8: Difference between revisions

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-[[Image:1bl8.png|left|200px]]
-<!--
+==POTASSIUM CHANNEL (KCSA) FROM STREPTOMYCES LIVIDANS==
-The line below this paragraph, containing "STRUCTURE_1bl8", creates the "Structure Box" on the page.
+<StructureSection load='1bl8' size='340' side='right'caption='[[1bl8]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1bl8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_lividans Streptomyces lividans]. The February 2003 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Potassium Channels''  by Shuchismita Dutta and David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2003_2 10.2210/rcsb_pdb/mom_2003_2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BL8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BL8 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
-{{STRUCTURE_1bl8|  PDB=1bl8  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bl8 OCA], [https://pdbe.org/1bl8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bl8 RCSB], [https://www.ebi.ac.uk/pdbsum/1bl8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bl8 ProSAT]</span></td></tr>
+</table>
-===POTASSIUM CHANNEL (KCSA) FROM STREPTOMYCES LIVIDANS===
+== Function ==
+[https://www.uniprot.org/uniprot/KCSA_STRLI KCSA_STRLI] Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).<ref>PMID:7489706</ref>
+== Evolutionary Conservation ==
-<!--
+[[Image:Consurf_key_small.gif|200px|right]]
-The line below this paragraph, {{ABSTRACT_PUBMED_9525859}}, adds the Publication Abstract to the page
+Check<jmol>
-(as it appears on PubMed at http://www.pubmed.gov), where 9525859 is the PubMed ID number.
+  <jmolCheckbox>
--->
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bl/1bl8_consurf.spt"</scriptWhenChecked>
-{{ABSTRACT_PUBMED_9525859}}
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
-==About this Structure==
+  </jmolCheckbox>
-[[1bl8]] is a 4 chain structure of [[Cation-pi interactions]], [[Glutamate receptor (GluA2)]] and [[Potassium Channel]] with sequence from [http://en.wikipedia.org/wiki/Streptomyces_lividans Streptomyces lividans]. The February 2003 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Potassium Channels''  by Shuchismita Dutta and David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2003_2 10.2210/rcsb_pdb/mom_2003_2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BL8 OCA].
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bl8 ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Amino Acids|Amino Acids]]
 *[[Cation-pi interactions|Cation-pi interactions]]
 *[[Glutamate receptor (GluA2)|Glutamate receptor (GluA2)]]
-*[[Nobel Prizes for 3D Molecular Structure|Nobel Prizes for 3D Molecular Structure]]
+*[[Ionotropic receptors|Ionotropic receptors]]
-*[[Potassium Channel|Potassium Channel]]
+*[[Potassium channel 3D structures|Potassium channel 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:009525859</ref><ref group="xtra">PMID:011836517</ref><ref group="xtra">PMID:011836519</ref><ref group="xtra">PMID:015565171</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Potassium Channels]]
 [[Category: RCSB PDB Molecule of the Month]]
 [[Category: Streptomyces lividans]]
-[[Category: Cabral, J M.]]
+[[Category: Cabral JM]]
-[[Category: Chait, B T.]]
+[[Category: Chait BT]]
-[[Category: Cohen, S L.]]
+[[Category: Cohen SL]]
-[[Category: Doyle, D A.]]
+[[Category: Doyle DA]]
-[[Category: Gulbis, J M.]]
+[[Category: Gulbis JM]]
-[[Category: Kuo, A.]]
+[[Category: Kuo A]]
-[[Category: Mackinnon, R.]]
+[[Category: Mackinnon R]]
-[[Category: Pfuetzner, R A.]]
+[[Category: Pfuetzner RA]]
-[[Category: Integral membrane protein]]
-[[Category: Membrane protein]]
-[[Category: Potassium channel]]