1bh9: Difference between revisions

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-[[Image:1bh9.gif|left|200px]]<br />
-<applet load="1bh9" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="1bh9, resolution 2.6&Aring;" />
-'''HTAFII18/HTAFII28 HETERODIMER CRYSTAL STRUCTURE WITH BOUND PCMBS'''<br />
-==Overview==
+==HTAFII18/HTAFII28 HETERODIMER CRYSTAL STRUCTURE WITH BOUND PCMBS==
-Determination of the crystal structure of the human TBP-associated factor, (hTAF(II))28/hTAF(II)18 heterodimer shows that these TAF(II)s form a novel, histone-like pair in the TFIID complex. The histone folds in hTAF(II)28, and hTAF(II)18 were not predicted from their primary sequence, indicating, that these TAF(II)s define a novel family of atypical histone fold, sequences. The TAF(II)18 and TAF(II)28 histone fold motifs are also, present in the N- and C-terminal regions of the SPT3 proteins, suggesting, that the histone fold in SPT3 may be reconstituted by intramolecular, rather than classical intermolecular interactions. The existence of, additional histone-like pairs in both the TFIID and SAGA complexes shows, that the histone fold is a more commonly used motif for mediating TAF-TAF, interactions than previously believed.
+<StructureSection load='1bh9' size='340' side='right'caption='[[1bh9]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1bh9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BH9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BH9 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PMB:PARA-MERCURY-BENZENESULFONIC+ACID'>PMB</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bh9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bh9 OCA], [https://pdbe.org/1bh9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bh9 RCSB], [https://www.ebi.ac.uk/pdbsum/1bh9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bh9 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/TAF13_HUMAN TAF13_HUMAN] TFIID beta-specific TAFII.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bh/1bh9_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bh9 ConSurf].
+<div style="clear:both"></div>
-==About this Structure==
+==See Also==
-BH9 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with PMB as [http://en.wikipedia.org/wiki/ligand ligand]. Structure known Active Site: MRY. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BH9 OCA].
+*[[Transcription initiation factors 3D structures|Transcription initiation factors 3D structures]]
+__TOC__
-==Reference==
+</StructureSection>
-Human TAF(II)28 and TAF(II)18 interact through a histone fold encoded by atypical evolutionary conserved motifs also found in the SPT3 family., Birck C, Poch O, Romier C, Ruff M, Mengus G, Lavigne AC, Davidson I, Moras D, Cell. 1998 Jul 24;94(2):239-49. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9695952 9695952]
 [[Category: Homo sapiens]]
-[[Category: Protein complex]]
+[[Category: Large Structures]]
-[[Category: Birck, C.]]
+[[Category: Birck C]]
-[[Category: Davidson, I.]]
+[[Category: Davidson I]]
-[[Category: Lavigne, A.C.]]
+[[Category: Lavigne A-C]]
-[[Category: Mengus, G.]]
+[[Category: Mengus G]]
-[[Category: Moras, D.]]
+[[Category: Moras D]]
-[[Category: Poch, O.]]
+[[Category: Poch O]]
-[[Category: Romier, C.]]
+[[Category: Romier C]]
-[[Category: Ruff, M.]]
+[[Category: Ruff M]]
-[[Category: PMB]]
-[[Category: histone fold]]
-[[Category: htafii18]]
-[[Category: tata binding protein]]
-[[Category: transcription regulation complex]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 16:09:37 2007''