1awc: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:1awc.gif|left|200px]]<br /><applet load="1awc" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="1awc, resolution 2.150&Aring;" />
-'''MOUSE GABP ALPHA/BETA DOMAIN BOUND TO DNA'''<br />
-==Overview==
+==MOUSE GABP ALPHA/BETA DOMAIN BOUND TO DNA==
-GA-binding protein (GABP) is a transcriptional regulator composed of two, structurally dissimilar subunits. The alpha subunit contains a DNA-binding, domain that is a member of the ETS family, whereas the beta subunit, contains a series of ankyrin repeats. The crystal structure of a ternary, complex containing a GABPalpha/beta ETS domain-ankyrin repeat heterodimer, bound to DNA was determined at 2. 15 angstrom resolution. The structure, shows how an ETS domain protein can recruit a partner protein using both, the ETS domain and a carboxyl-terminal extension and provides a view of an, extensive protein-protein interface formed by a set of ankyrin repeats., The structure also reveals how the GABPalpha ETS domain binds to its core, GGA DNA-recognition motif.
+<StructureSection load='1awc' size='340' side='right'caption='[[1awc]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
+== Structural highlights ==
-==About this Structure==
+<table><tr><td colspan='2'>[[1awc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AWC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AWC FirstGlance]. <br>
-AWC is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AWC OCA].
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BRU:5-BROMO-2-DEOXYURIDINE-5-MONOPHOSPHATE'>BRU</scene>, <scene name='pdbligand=CBR:5-BROMO-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>CBR</scene></td></tr>
-==Reference==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1awc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1awc OCA], [https://pdbe.org/1awc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1awc RCSB], [https://www.ebi.ac.uk/pdbsum/1awc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1awc ProSAT]</span></td></tr>
-The structure of GABPalpha/beta: an ETS domain- ankyrin repeat heterodimer bound to DNA., Batchelor AH, Piper DE, de la Brousse FC, McKnight SL, Wolberger C, Science. 1998 Feb 13;279(5353):1037-41. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9461436 9461436]
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/GABPA_MOUSE GABPA_MOUSE] Transcription factor capable of interacting with purine rich repeats (GA repeats).
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/aw/1awc_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1awc ConSurf].
+<div style="clear:both"></div>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Mus musculus]]
-[[Category: Protein complex]]
+[[Category: Batchelor AH]]
-[[Category: Batchelor, A.H.]]
+[[Category: Wolberger C]]
-[[Category: Wolberger, C.]]
-[[Category: ankyrin repeats]]
-[[Category: complex (transcription regulation/dna)]]
-[[Category: dna-binding]]
-[[Category: ets domain]]
-[[Category: nuclear protein]]
-[[Category: transcription factor]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 11:10:21 2007''