1au7: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

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-{{Seed}}
-[[Image:1au7.png|left|200px]]
-<!--
+==PIT-1 MUTANT/DNA COMPLEX==
-The line below this paragraph, containing "STRUCTURE_1au7", creates the "Structure Box" on the page.
+<StructureSection load='1au7' size='340' side='right'caption='[[1au7]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1au7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AU7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AU7 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1au7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1au7 OCA], [https://pdbe.org/1au7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1au7 RCSB], [https://www.ebi.ac.uk/pdbsum/1au7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1au7 ProSAT]</span></td></tr>
-{{STRUCTURE_1au7|  PDB=1au7  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PIT1_RAT PIT1_RAT] Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'-TAAAT-3'.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/au/1au7_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1au7 ConSurf].
+<div style="clear:both"></div>
-===PIT-1 MUTANT/DNA COMPLEX===
+==See Also==
+*[[Art:Molecular Sculpture|Art:Molecular Sculpture]]
+__TOC__
-<!--
+</StructureSection>
-The line below this paragraph, {{ABSTRACT_PUBMED_9009203}}, adds the Publication Abstract to the page
+[[Category: Large Structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 9009203 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_9009203}}
-==About this Structure==
-AU7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AU7 OCA].
-==Reference==
-Structure of Pit-1 POU domain bound to DNA as a dimer: unexpected arrangement and flexibility., Jacobson EM, Li P, Leon-del-Rio A, Rosenfeld MG, Aggarwal AK, Genes Dev. 1997 Jan 15;11(2):198-212. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9009203 9009203]
 [[Category: Rattus norvegicus]]
-[[Category: Single protein]]
+[[Category: Aggarwal AK]]
-[[Category: Aggarwal, A K.]]
+[[Category: Jacobson EM]]
-[[Category: Jacobson, E M.]]
+[[Category: Leon-Del-Rio A]]
-[[Category: Leon-Del-Rio, A.]]
+[[Category: Li P]]
-[[Category: Li, P.]]
+[[Category: Rosenfeld MG]]
-[[Category: Rosenfeld, M G.]]
-[[Category: Cphd]]
-[[Category: Pituitary]]
-[[Category: Pou domain]]
-[[Category: Transcription factor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:36:10 2008''