1aqx: Difference between revisions

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-[[Image:1aqx.png|left|200px]]
-<!--
+==GLUTATHIONE S-TRANSFERASE IN COMPLEX WITH MEISENHEIMER COMPLEX==
-The line below this paragraph, containing "STRUCTURE_1aqx", creates the "Structure Box" on the page.
+<StructureSection load='1aqx' size='340' side='right'caption='[[1aqx]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1aqx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AQX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AQX FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTD:1-(S-GLUTATHIONYL)-2,4,6-TRINITROCYCLOHEXA-2,5-DIENE'>GTD</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
-{{STRUCTURE_1aqx|  PDB=1aqx  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1aqx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aqx OCA], [https://pdbe.org/1aqx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1aqx RCSB], [https://www.ebi.ac.uk/pdbsum/1aqx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1aqx ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/GSTP1_HUMAN GSTP1_HUMAN] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.<ref>PMID:21668448</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/aq/1aqx_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1aqx ConSurf].
+<div style="clear:both"></div>
-===GLUTATHIONE S-TRANSFERASE IN COMPLEX WITH MEISENHEIMER COMPLEX===
+==See Also==
+*[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]]
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_9351803}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 9351803 is the PubMed ID number.
+</StructureSection>
--->
-{{ABSTRACT_PUBMED_9351803}}
-==About this Structure==
-[[1aqx]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AQX OCA].
-==Reference==
-<ref group="xtra">PMID:009351803</ref><references group="xtra"/>
-[[Category: Glutathione transferase]]
 [[Category: Homo sapiens]]
-[[Category: Fahl, W E.]]
+[[Category: Large Structures]]
-[[Category: Huber, R.]]
+[[Category: Fahl WE]]
-[[Category: Manoharan, T H.]]
+[[Category: Huber R]]
-[[Category: Prade, L.]]
+[[Category: Manoharan TH]]
-[[Category: Reuter, W.]]
+[[Category: Prade L]]
-[[Category: Class pi]]
+[[Category: Reuter W]]
-[[Category: Glutathione s-transferase]]
-[[Category: Transferase]]
-[[Category: Transferase-substrate complex]]
-[[Category: Transition state]]