1akc: Difference between revisions

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-[[Image:1akc.png|left|200px]]
-{{STRUCTURE_1akc|  PDB=1akc  |  SCENE=  }}
+==Structural basis for the catalytic activity of aspartate aminotransferase K258H lacking its pyridoxal-5'-phosphate-binding lysine residue==
+<StructureSection load='1akc' size='340' side='right'caption='[[1akc]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-===Structural basis for the catalytic activity of aspartate aminotransferase K258H lacking its pyridoxal-5'-phosphate-binding lysine residue===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1akc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AKC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AKC FirstGlance]. <br>
-{{ABSTRACT_PUBMED_7819232}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PPE:4-[(1,3-DICARBOXY-PROPYLAMINO)-METHYL]-3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDINIUM'>PPE</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1akc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1akc OCA], [https://pdbe.org/1akc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1akc RCSB], [https://www.ebi.ac.uk/pdbsum/1akc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1akc ProSAT]</span></td></tr>
-[[1akc]] is a 1 chain structure of [[Aspartate Aminotransferase]] with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AKC OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/AATM_CHICK AATM_CHICK] Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. May facilitate cellular uptake of long-chain free fatty acids (By similarity).
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ak/1akc_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1akc ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Aspartate Aminotransferase|Aspartate Aminotransferase]]
+*[[Aspartate aminotransferase 3D structures|Aspartate aminotransferase 3D structures]]
+__TOC__
-==Reference==
+</StructureSection>
-<ref group="xtra">PMID:007819232</ref><references group="xtra"/>
-[[Category: Aspartate transaminase]]
 [[Category: Gallus gallus]]
-[[Category: Jansonius, J N.]]
+[[Category: Large Structures]]
-[[Category: Malashkevich, V N.]]
+[[Category: Jansonius JN]]
+[[Category: Malashkevich VN]]