1aj0: Difference between revisions

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-{{Seed}}
-[[Image:1aj0.png|left|200px]]
-<!--
+==CRYSTAL STRUCTURE OF A TERNARY COMPLEX OF E. COLI DIHYDROPTEROATE SYNTHASE==
-The line below this paragraph, containing "STRUCTURE_1aj0", creates the "Structure Box" on the page.
+<StructureSection load='1aj0' size='340' side='right'caption='[[1aj0]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1aj0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AJ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AJ0 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PH2:2-AMINO-6-HYDROXYMETHYL-7,8-DIHYDRO-3H-PTERIDIN-4-ONE'>PH2</scene>, <scene name='pdbligand=SAN:SULFANILAMIDE'>SAN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-{{STRUCTURE_1aj0|  PDB=1aj0  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1aj0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aj0 OCA], [https://pdbe.org/1aj0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1aj0 RCSB], [https://www.ebi.ac.uk/pdbsum/1aj0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1aj0 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/DHPS_ECOLI DHPS_ECOLI] DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide.<ref>PMID:368012</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/aj/1aj0_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1aj0 ConSurf].
+<div style="clear:both"></div>
-===CRYSTAL STRUCTURE OF A TERNARY COMPLEX OF E. COLI DIHYDROPTEROATE SYNTHASE===
+==See Also==
+*[[Dihydropteroate synthase 3D structures|Dihydropteroate synthase 3D structures]]
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_9187658}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 9187658 is the PubMed ID number.
+</StructureSection>
--->
-{{ABSTRACT_PUBMED_9187658}}
-==About this Structure==
-AJ0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AJ0 OCA].
-==Reference==
-Crystal structure of the anti-bacterial sulfonamide drug target dihydropteroate synthase., Achari A, Somers DO, Champness JN, Bryant PK, Rosemond J, Stammers DK, Nat Struct Biol. 1997 Jun;4(6):490-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9187658 9187658]
-[[Category: Dihydropteroate synthase]]
 [[Category: Escherichia coli]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Achari, A.]]
+[[Category: Achari A]]
-[[Category: Bryant, P K.]]
+[[Category: Bryant PK]]
-[[Category: Champness, J N.]]
+[[Category: Champness JN]]
-[[Category: Rosemond, J.]]
+[[Category: Rosemond J]]
-[[Category: Somers, D O.]]
+[[Category: Somers DO]]
-[[Category: Stammers, D K.]]
+[[Category: Stammers DK]]
-[[Category: Antibiotic]]
-[[Category: Biosynthesis]]
-[[Category: Folate]]
-[[Category: Resistance]]
-[[Category: Synthase]]
-[[Category: Transferase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:57:10 2008''