1agx: Difference between revisions

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<StructureSection load='1agx' size='340' side='right'caption='[[1agx]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
<StructureSection load='1agx' size='340' side='right'caption='[[1agx]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1agx]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AGX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1AGX FirstGlance]. <br>
<table><tr><td colspan='2'>[[1agx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_glutaminasificans Acinetobacter glutaminasificans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AGX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AGX FirstGlance]. <br>
</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Asparaginase Asparaginase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.1 3.5.1.1] </span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1agx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1agx OCA], [http://pdbe.org/1agx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1agx RCSB], [http://www.ebi.ac.uk/pdbsum/1agx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1agx ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1agx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1agx OCA], [https://pdbe.org/1agx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1agx RCSB], [https://www.ebi.ac.uk/pdbsum/1agx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1agx ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ASPQ_ACIGL ASPQ_ACIGL]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1agx ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1agx ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The crystal structure of glutaminase-asparaginase from Acinetobacter glutaminasificans has been reinterpreted and refined to an R factor of 0.171 at 2.9 A resolution, using the same X-ray diffraction data that were used to build a preliminary model of this enzyme [Ammon, Weber, Wlodawer, Harrison, Gilliland, Murphy, Sjolin &amp; Roberts (1988). J. Biol. Chem. 263, 150-156]. The current model, which does not include solvent, is based in part on the related structure of Escherichia coli asparaginase and is significantly different from the structure of the enzyme from A. glutaminasificans described previously. The reason for the discrepancies has been traced to insufficient phasing power of the original heavy-atom derivative data, which could not be compensated for fully by electron-density modification techniques. The corrected structure of A. glutaminasificans glutaminase-asparaginase is presented and compared with the preliminary model and with the structure of E. coli asparaginase.
Refined crystal structure of Acinetobacter glutaminasificans glutaminase-asparaginase.,Lubkowski J, Wlodawer A, Housset D, Weber IT, Ammon HL, Murphy KC, Swain AL Acta Crystallogr D Biol Crystallogr. 1994 Nov 1;50(Pt 6):826-32. PMID:15299349<ref>PMID:15299349</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1agx" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Glutaminase|Glutaminase]]
*[[Glutaminase 3D structures|Glutaminase 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Asparaginase]]
[[Category: Acinetobacter glutaminasificans]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Ammon, H L]]
[[Category: Ammon HL]]
[[Category: Housset, D]]
[[Category: Housset D]]
[[Category: Lubkowski, J]]
[[Category: Lubkowski J]]
[[Category: Murphy, K C]]
[[Category: Murphy KC]]
[[Category: Swain, A L]]
[[Category: Swain AL]]
[[Category: Weber, I T]]
[[Category: Weber IT]]
[[Category: Wlodawer, A]]
[[Category: Wlodawer A]]
[[Category: Bacterial amidohydrolase]]

Latest revision as of 09:30, 7 February 2024

REFINED CRYSTAL STRUCTURE OF ACINETOBACTER GLUTAMINASIFICANS GLUTAMINASE-ASPARAGINASEREFINED CRYSTAL STRUCTURE OF ACINETOBACTER GLUTAMINASIFICANS GLUTAMINASE-ASPARAGINASE

Structural highlights

1agx is a 1 chain structure with sequence from Acinetobacter glutaminasificans. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.9Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ASPQ_ACIGL

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1agx, resolution 2.90Å

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