1aew: Difference between revisions

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{{Seed}}
[[Image:1aew.png|left|200px]]


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==L-CHAIN HORSE APOFERRITIN==
The line below this paragraph, containing "STRUCTURE_1aew", creates the "Structure Box" on the page.
<StructureSection load='1aew' size='340' side='right'caption='[[1aew]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1aew]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. The November 2002 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Ferritin and Transferrin''  by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2002_11 10.2210/rcsb_pdb/mom_2002_11]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AEW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AEW FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
{{STRUCTURE_1aew| PDB=1aew |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1aew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aew OCA], [https://pdbe.org/1aew PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1aew RCSB], [https://www.ebi.ac.uk/pdbsum/1aew PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1aew ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FRIL_HORSE FRIL_HORSE] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ae/1aew_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1aew ConSurf].
<div style="clear:both"></div>


===L-CHAIN HORSE APOFERRITIN===
==See Also==
 
*[[Ferritin 3D structures|Ferritin 3D structures]]
 
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{{ABSTRACT_PUBMED_9159481}}
 
==About this Structure==
1AEW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Additional information on 1AEW is available in a page on [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb35_1.html Ferritin and Transferrin] at the RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AEW OCA].
 
==Reference==
Comparison of the three-dimensional structures of recombinant human H and horse L ferritins at high resolution., Hempstead PD, Yewdall SJ, Fernie AR, Lawson DM, Artymiuk PJ, Rice DW, Ford GC, Harrison PM, J Mol Biol. 1997 May 2;268(2):424-48. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9159481 9159481]
[[Category: Equus caballus]]
[[Category: Equus caballus]]
[[Category: Ferritin and Transferrin]]
[[Category: Ferritin and Transferrin]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Artymiuk, P J.]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: Harrison, P M.]]
[[Category: Artymiuk PJ]]
[[Category: Hempstead, P D.]]
[[Category: Harrison PM]]
[[Category: Lawson, D M.]]
[[Category: Hempstead PD]]
[[Category: Yewdall, S J.]]
[[Category: Lawson DM]]
[[Category: Acetylation]]
[[Category: Yewdall SJ]]
[[Category: Iron storage]]
[[Category: Multigene family]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 23 11:04:45 2008''

Latest revision as of 09:30, 7 February 2024

L-CHAIN HORSE APOFERRITINL-CHAIN HORSE APOFERRITIN

Structural highlights

1aew is a 1 chain structure with sequence from Equus caballus. The November 2002 RCSB PDB Molecule of the Month feature on Ferritin and Transferrin by David S. Goodsell is 10.2210/rcsb_pdb/mom_2002_11. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.95Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

FRIL_HORSE Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1aew, resolution 1.95Å

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