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[[Image:1aew.gif|left|200px]]<br />
<applet load="1aew" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1aew, resolution 1.95&Aring;" />
'''L-CHAIN HORSE APOFERRITIN'''<br />


==Overview==
==L-CHAIN HORSE APOFERRITIN==
Mammalian ferritins are 24-mers assembled from two types of polypeptide, chain which provide the molecule with different functions. H(eavy) chains, catalyse the first step in iron storage, the oxidation of iron(II)., L(ight) chains promote the nucleation of the mineral ferrihydrite enabling, storage of iron(III) inside the protein shell. We report here the, comparison of the three-dimensional structures of recombinant human H, chain (HuHF) and horse L chain (HoLF) ferritin homopolymers, which have, been refined at 1.9 A resolution. There is 53% sequence identity between, these molecules, and the two structures are very similar, the H and L, subunit alpha-carbons superposing to within 0.5 A rms deviation with 41, water molecules in common. Nevertheless, there are significant important, ... [[http://ispc.weizmann.ac.il/pmbin/getpm?9159481 (full description)]]
<StructureSection load='1aew' size='340' side='right'caption='[[1aew]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1aew]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. The November 2002 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Ferritin and Transferrin''  by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2002_11 10.2210/rcsb_pdb/mom_2002_11]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AEW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AEW FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1aew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aew OCA], [https://pdbe.org/1aew PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1aew RCSB], [https://www.ebi.ac.uk/pdbsum/1aew PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1aew ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FRIL_HORSE FRIL_HORSE] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ae/1aew_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1aew ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
1AEW is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]] with CD as [[http://en.wikipedia.org/wiki/ligand ligand]]. The following page contains interesting information on the relation of 1AEW with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb35_1.html Ferritin and Transferrin]]. Structure known Active Sites: NCL, SS1, SS2 and SS3. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AEW OCA]].
*[[Ferritin 3D structures|Ferritin 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
Comparison of the three-dimensional structures of recombinant human H and horse L ferritins at high resolution., Hempstead PD, Yewdall SJ, Fernie AR, Lawson DM, Artymiuk PJ, Rice DW, Ford GC, Harrison PM, J Mol Biol. 1997 May 2;268(2):424-48. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9159481 9159481]
[[Category: Equus caballus]]
[[Category: Equus caballus]]
[[Category: Ferritin and Transferrin]]
[[Category: Ferritin and Transferrin]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Artymiuk, P.J.]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: Harrison, P.M.]]
[[Category: Artymiuk PJ]]
[[Category: Hempstead, P.D.]]
[[Category: Harrison PM]]
[[Category: Lawson, D.M.]]
[[Category: Hempstead PD]]
[[Category: Yewdall, S.J.]]
[[Category: Lawson DM]]
[[Category: CD]]
[[Category: Yewdall SJ]]
[[Category: acetylation]]
[[Category: iron storage]]
[[Category: multigene family]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 08:37:39 2007''

Latest revision as of 09:30, 7 February 2024

L-CHAIN HORSE APOFERRITINL-CHAIN HORSE APOFERRITIN

Structural highlights

1aew is a 1 chain structure with sequence from Equus caballus. The November 2002 RCSB PDB Molecule of the Month feature on Ferritin and Transferrin by David S. Goodsell is 10.2210/rcsb_pdb/mom_2002_11. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.95Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

FRIL_HORSE Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1aew, resolution 1.95Å

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