1aei: Difference between revisions

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<StructureSection load='1aei' size='340' side='right'caption='[[1aei]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='1aei' size='340' side='right'caption='[[1aei]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1aei]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Hydvu Hydvu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AEI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1AEI FirstGlance]. <br>
<table><tr><td colspan='2'>[[1aei]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Hydra_vulgaris Hydra vulgaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AEI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AEI FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1aei FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aei OCA], [http://pdbe.org/1aei PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1aei RCSB], [http://www.ebi.ac.uk/pdbsum/1aei PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1aei ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1aei FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aei OCA], [https://pdbe.org/1aei PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1aei RCSB], [https://www.ebi.ac.uk/pdbsum/1aei PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1aei ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ANX12_HYDVU ANX12_HYDVU]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1aei ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1aei ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Annexins are a family of calcium- and phospholipid-binding proteins implicated in a number of biological processes including membrane fusion and ion channel formation. The crystal structure of the annexin XII hexamer, refined at 2.8 A resolution, forms a concave disk with 3-2 symmetry, about 100 A in diameter and 70 A thick with a central hydrophilic pore. Six intermolecular Ca2+ ions are involved in hexamer formation. An additional 18 Ca2+ ions are located on the perimeter of the disk, accessible only from the side of the hexameric disk. On the basis of the hexamer structure we propose here a new mode of protein-phospholipid bilayer interaction that is distinct from the hydrophobic insertion of typical membrane proteins. This speculative model postulates the Ca(2+)-dependent insertion of the hydrophilic annexin XII hexamer into phospholipid bilayers with local reorientation of the bilayer phospholipids.
Crystal structure of the annexin XII hexamer and implications for bilayer insertion.,Luecke H, Chang BT, Mailliard WS, Schlaepfer DD, Haigler HT Nature. 1995 Nov 30;378(6556):512-5. PMID:7477411<ref>PMID:7477411</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1aei" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Annexin 3D structures|Annexin 3D structures]]
*[[Annexin 3D structures|Annexin 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Hydvu]]
[[Category: Hydra vulgaris]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Chang, B T]]
[[Category: Chang BT]]
[[Category: Haigler, H T]]
[[Category: Haigler HT]]
[[Category: Luecke, H]]
[[Category: Luecke H]]
[[Category: Mailliard, W S]]
[[Category: Mailliard WS]]
[[Category: Schlaepfer, D D]]
[[Category: Schlaepfer DD]]
[[Category: Annexin]]
[[Category: Calcium]]
[[Category: Calcium-phospholipid-binding complex]]
[[Category: Calcium/phospholipid-binding]]
[[Category: Phospholipid]]

Latest revision as of 09:30, 7 February 2024

CRYSTAL STRUCTURE OF THE ANNEXIN XII HEXAMERCRYSTAL STRUCTURE OF THE ANNEXIN XII HEXAMER

Structural highlights

1aei is a 6 chain structure with sequence from Hydra vulgaris. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.8Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ANX12_HYDVU

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1aei, resolution 2.80Å

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