1aa2: Difference between revisions

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-[[Image:1aa2.gif|left|200px]]
- {{Structure
+==CALPONIN HOMOLOGY (CH) DOMAIN FROM HUMAN BETA-SPECTRIN==
-|PDB= 1aa2 |SIZE=350|CAPTION= <scene name='initialview01'>1aa2</scene>, resolution 2.0&Aring;
+<StructureSection load='1aa2' size='340' side='right'caption='[[1aa2]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND=
+<table><tr><td colspan='2'>[[1aa2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AA2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AA2 FirstGlance]. <br>
-|ACTIVITY=
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-|GENE=
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1aa2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aa2 OCA], [https://pdbe.org/1aa2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1aa2 RCSB], [https://www.ebi.ac.uk/pdbsum/1aa2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1aa2 ProSAT]</span></td></tr>
-}}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/SPTB2_HUMAN SPTB2_HUMAN] Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/aa/1aa2_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1aa2 ConSurf].
+<div style="clear:both"></div>
-'''CALPONIN HOMOLOGY (CH) DOMAIN FROM HUMAN BETA-SPECTRIN'''
+==See Also==
+*[[Spectrin 3D structures|Spectrin 3D structures]]
+__TOC__
-==Overview==
+</StructureSection>
-The three-dimensional structure of the calponin homology domain present in many actin binding cytoskeletal and signal-transducing proteins has been determined at 2.0 A resolution.
-==About this Structure==
-AA2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AA2 OCA].
-==Reference==
-Crystal structure of a calponin homology domain., Djinovic Carugo K, Banuelos S, Saraste M, Nat Struct Biol. 1997 Mar;4(3):175-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9164454 9164454]
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Banuelos, S.]]
+[[Category: Banuelos S]]
-[[Category: Carugo, K Djinovic.]]
+[[Category: Djinovic Carugo K]]
-[[Category: Saraste, M.]]
+[[Category: Saraste M]]
-[[Category: cytoskeleton]]
-[[Category: f-actin cross-linking]]
-[[Category: spectrin]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 09:55:01 2008''