1a4i: Difference between revisions

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-[[Image:1a4i.png|left|200px]]
-<!--
+==HUMAN TETRAHYDROFOLATE DEHYDROGENASE / CYCLOHYDROLASE==
-The line below this paragraph, containing "STRUCTURE_1a4i", creates the "Structure Box" on the page.
+<StructureSection load='1a4i' size='340' side='right'caption='[[1a4i]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1a4i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A4I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A4I FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
-{{STRUCTURE_1a4i|  PDB=1a4i  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a4i OCA], [https://pdbe.org/1a4i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a4i RCSB], [https://www.ebi.ac.uk/pdbsum/1a4i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a4i ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/C1TC_HUMAN C1TC_HUMAN] Defects in MTHFD1 may be a cause of susceptibility to folate-sensitive neural tube defects (FS-NTD) [MIM:[https://omim.org/entry/601634 601634]. The most common NTDs are open spina bifida (myelomeningocele) and anencephaly. Genetic defects in MTHFD1 may affect the risk of spina bifida via the maternal rather than the embryonic genotype.<ref>PMID:9611072</ref> <ref>PMID:12384833</ref> <ref>PMID:16552426</ref>   Genetic variation in MTHFD1 could be associated with susceptibility to colorectal cancer (CRC) [MIM:[https://omim.org/entry/114500 114500].
+== Function ==
+[https://www.uniprot.org/uniprot/C1TC_HUMAN C1TC_HUMAN]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a4/1a4i_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a4i ConSurf].
+<div style="clear:both"></div>
-===HUMAN TETRAHYDROFOLATE DEHYDROGENASE / CYCLOHYDROLASE===
+==See Also==
+*[[Cyclohydrolase 3D structures|Cyclohydrolase 3D structures]]
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_9519408}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 9519408 is the PubMed ID number.
+</StructureSection>
--->
-{{ABSTRACT_PUBMED_9519408}}
-==About this Structure==
-[[1a4i]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A4I OCA].
-==Reference==
-<ref group="xtra">PMID:009519408</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Allaire, M.]]
+[[Category: Large Structures]]
-[[Category: Cygler, M.]]
+[[Category: Allaire M]]
-[[Category: Li, Y.]]
+[[Category: Cygler M]]
-[[Category: Mackenzie, R E.]]
+[[Category: Li Y]]
-[[Category: Bifunctional]]
+[[Category: Mackenzie RE]]
-[[Category: Cyclohydrolase]]
-[[Category: Dehydrogenase]]
-[[Category: Folate]]
-[[Category: Oxidoreductase]]
-[[Category: Thf]]